» Articles » PMID: 25858871

Selenium and Selenium-dependent Antioxidants in Chronic Kidney Disease

Overview
Journal Adv Clin Chem
Specialty Biochemistry
Date 2015 Apr 11
PMID 25858871
Citations 46
Authors
Affiliations
Soon will be listed here.
Abstract

Oxidative stress plays a key role in numerous disease processes including chronic kidney disease (CKD). In general, oxygen metabolism leads to the formation of reactive oxygen species (ROS) dangerous to cells. Although enzymes and low-molecular-weight antioxidants protect against ROS, chronic imbalances of formation and elimination can eventually overwhelm endogenous defenses leading to deleterious consequences. In CKD, glutathione peroxidases (GSH-Px) play an important role in ROS metabolism. Plasma GSH-Px is synthesized in the kidney and requires selenium (Se) as a cofactor. Interestingly, Se and plasma GSH-Px are both significantly reduced in CKD, especially for those patients on hemodialysis. Supplementation of Se in these patients results in modest increases of GSH-Px, presumably from residual renal tissue. Kidney transplantation rapidly restores plasma GSH-Px. In this chapter, the relevance of these findings to CKD is explored with emphasis on renal disease processes and impact on attendant disorders including cancer and cardiovascular disease.

Citing Articles

Circulating Glutathione Peroxidase-3 in Elderly-Association with Renal Function, Cardiovascular Mortality, and Impact of Selenium and Coenzyme Q Supplementation.

Alexander J, Aaseth J, Schomburg L, Chillon T, Larsson A, Alehagen U Antioxidants (Basel). 2025; 13(12.

PMID: 39765894 PMC: 11672870. DOI: 10.3390/antiox13121566.


Investigation of Trace and Macro Element Contents in Commercial Cat Foods.

Bilgic B, Tarhan D, Ates F, Parkan Yaramis C, Koenhemsi L, Or M Vet Med Sci. 2024; 11(1):e70123.

PMID: 39661029 PMC: 11633335. DOI: 10.1002/vms3.70123.


Selenium, a Notable Micronutrient: A Crucial Element in the Context of All-Cause Long-Term Mortality in Renal Failure.

Tutan D, Ulfberg J, Aydemir N, Eser B, Dogan I Biol Trace Elem Res. 2024; .

PMID: 39589683 DOI: 10.1007/s12011-024-04460-6.


High salt diet accelerates skin aging in wistar rats: an 8-week investigation of cell cycle inhibitors, SASP markers, and oxidative stress.

Peng X, Liu N, Zeng B, Bai Y, Xu Y, Chen Y Front Bioeng Biotechnol. 2024; 12:1450626.

PMID: 39465002 PMC: 11502324. DOI: 10.3389/fbioe.2024.1450626.


Association of the oxidative balance score and chronic kidney disease: insights from the national health and nutrition examination survey 2009-2018.

Chen X, Wu Z, Hou X, Yu W, Gao C, Gou S Front Nutr. 2024; 11:1429191.

PMID: 39399530 PMC: 11468420. DOI: 10.3389/fnut.2024.1429191.