Design of an Osteoinductive Extracellular Fibronectin Matrix Protein for Bone Tissue Engineering

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2015 Apr 9

PMID 25853265

Citations 4

Authors

Sujin Lee

Dong-Sung Lee

Ilsan Choi

Le B Hang Pham

Jun-Hyeog Jang

Affiliations

Soon will be listed here.

Abstract

Integrin-mediated cell-matrix interactions play an important role in osteogenesis. Here, we constructed a novel osteoinductive fibronectin matrix protein (oFN) for bone tissue engineering, designed to combine the integrin-binding modules from fibronectin (iFN) and a strong osteoinductive growth factor, bone morphogenetic protein-2. Compared with iFN, the purified oFN matrix protein caused a significant increase in cell adhesion and osteogenic differentiation of pre-osteoblast MC3T3-E1 cells (p < 0.05).

Citing Articles

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Feng L, Li Y, Zeng W, Xia B, Zhou D, Zhou J Exp Ther Med. 2017; 14(6):6087-6092.

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