Endoscopic Ultrasonography-guided Ethanol Ablation for Small Pancreatic Neuroendocrine Tumors: Results of a Pilot Study

Overview

Journal Clin Endosc

Date 2015 Apr 7

PMID 25844345

Citations 38

Authors

Do Hyun Park

Jun-Ho Choi

Dongwook Oh

Sang Soo Lee

Dong-Wan Seo

Sung Koo Lee

Myung-Hwan Kim

Affiliations

Soon will be listed here.

Abstract

Background/aims: Endoscopic ultrasonography (EUS)-guided ethanol ablation is gaining popularity for the treatment of focal pancreatic lesions. The aim of this study was to evaluate the safety, feasibility, and treatment response after EUS-guided ethanol injection for small pancreatic neuroendocrine tumors (p-NETs).

Methods: This was a retrospective analysis of a prospectively collected database including 11 consecutive patients with p-NETs who underwent EUS-guided ethanol injection.

Results: EUS-guided ethanol injection was successfully performed in 11 patients with 14 tumors. The final diagnosis was based on histology and clinical signs as follows: 10 non-functioning neuroendocrine tumors and four insulinomas. During follow-up (median, 370 days; range, 152 to 730 days), 10 patients underwent clinical follow-up after treatment, and one patient was excluded because of loss to follow-up. A single treatment session with an injection of 0.5 to 3.8 mL of ethanol resulted in complete responses (CRs) at the 3-month radiologic imaging for seven of 13 tumors (response rate, 53.8%). Multiple treatment sessions performed in three tumors with residual viable enhancing tissue increased the number of tumors with CRs to eight of 13 (response rate, 61.5%). Mild pancreatitis occurred in three of 11 patients.

Conclusions: EUS-guided ethanol injection appears to be a safe, feasible, and potentially effective method for treating small p-NETs in patients who are poor surgical candidates.

Citing Articles

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Portuguese Pancreatic Club Perspectives on Endoscopic Ultrasound-Guided and Surgical Treatment of Pancreatic Neuroendocrine Tumors.

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An Overview of Pancreatic Neuroendocrine Tumors and an Update on Endoscopic Techniques for Their Management.

Elkelany O, Karaisz F, Davies B, Krishna S Curr Oncol. 2023; 30(8):7566-7580.

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Endoscopic Ultrasound-Guided Local Ablative Therapies for the Treatment of Pancreatic Neuroendocrine Tumors and Cystic Lesions: A Review of the Current Literature.

Prete A, Gonda T J Clin Med. 2023; 12(9).

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