Interactions Between Innate Immunity Genes and Early-life Risk Factors in Allergic Rhinitis

Overview

Journal Allergy Asthma Immunol Res

Date 2015 Apr 5

PMID 25840711

Citations 16

Authors

Ju Hee Seo

Hyung Young Kim

Young Ho Jung

Eun Lee

Song I Yang

Ho Sung Yu

Young Joon Kim

Mi Jin Kang

Ha Jung Kim

Kang Seo Park

Ji Won Kwon

Byung Ju Kim

Hyo Bin Kim

Eun Jin Kim

Joo Shil Lee

So Yeon Lee

Soo Jong Hong

Affiliations

Soon will be listed here.

Abstract

Purpose: Allergic rhinitis (AR) is a common chronic disease. Many factors could affect the development of AR. We investigated early-life factors, such as delivery mode, feeding method, and use of antibiotics during infancy, which could affect the development of AR. In addition, how interactions between these factors and innate gene polymorphisms influence the development of AR was investigated.

Methods: A cross-sectional study of 1,828 children aged 9-12 years was conducted. Three early-life factors and AR were assessed by a questionnaire. Skin prick tests were done. Polymorphisms of TLR4 (rs1927911) and CD14 (rs2569190) were genotyped.

Results: Use of antibiotics during infancy increased the risk of AR (aOR [95% CI] 1.511 [1.222-2.037]) and atopic AR (aOR [95% CI], 1.565 [1.078-2.272]). There were synergistic interactions between caesarean delivery, formula feeding, and use of antibiotics in the rate of atopic AR (aOR [95% CI], 3.038 [1.256-7.347]). Additional analyses revealed that the risk for the development of AR or atopic AR subjects with the TLR4 CC genotype were highest when all the 3 early-life factors were present (aOR [95% CI], 5.127 [1.265-20.780] for AR; 6.078 [1.499-24.649] for atopic AR). In addition, the risk for the development of AR or atopic AR in subjects with the CD14 TT genotype were highest when all the 3 early-life factors were present (aOR [95% CI], 5.960 [1.421-15.002] for AR; 6.714 [1.440-31.312] for atopic AR).

Conclusions: Delivery mode, feeding method, and use of antibiotics during infancy appeared to have synergistic interactions in the development of AR. Gene-environment interactions between polymorphism of innate genes and early- life risk factors might affect the development of AR.

Citing Articles

The global/local (limited to some regions) effect of cesarean delivery on the risk of pediatric allergic rhinitis: a systematic review and meta-analysis.

He X, Zhang S, Wu J, Fu Q, Zhang Q, Peng W Front Pediatr. 2023; 11:1228737.

PMID: 37601128 PMC: 10435734. DOI: 10.3389/fped.2023.1228737.

Blood eosinophil related to maternal allergic rhinitis is associated with the incidence of allergic rhinitis in offspring: COCOA study.

Choi E, Nah G, Chang W, Lee S, Suh D, Kim K BMC Pediatr. 2023; 23(1):343.

PMID: 37415120 PMC: 10324231. DOI: 10.1186/s12887-023-04156-1.

The Influence of Cesarean Section on the Composition and Development of Gut Microbiota During the First 3 Months of Life.

Long G, Hu Y, Tao E, Chen B, Shu X, Zheng W Front Microbiol. 2021; 12:691312.

PMID: 34489887 PMC: 8416498. DOI: 10.3389/fmicb.2021.691312.

The Association Between Intestinal Bacteria and Allergic Diseases-Cause or Consequence?.

Han P, Gu J, Li L, Wang X, Wang H, Wang Y Front Cell Infect Microbiol. 2021; 11:650893.

PMID: 33937097 PMC: 8083053. DOI: 10.3389/fcimb.2021.650893.

Risk factor analysis of allergic rhinitis in 6-8 year-old children in Taipei.

Ho C, Wu W PLoS One. 2021; 16(4):e0249572.

PMID: 33798255 PMC: 8018651. DOI: 10.1371/journal.pone.0249572.

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