Investigation of the Vitamin D Receptor Polymorphisms in Acromegaly Patients

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2015 Apr 4

PMID 25839036

Citations 5

Authors

Muzaffer Ilhan

Bahar Toptas-Hekimoglu

Ilhan Yaylim

Seda Turgut

Saime Turan

Ozcan Karaman

Ertugrul Tasan

Affiliations

Soon will be listed here.

Abstract

Objective: The genetic structural alterations in the majority of somatotroph adenomas are not clarified and the search for novel candidate genes is still a challenge. We aimed to investigate possible associations between vitamin D receptor (VDR) polymorphisms and acromegaly.

Design, Patients, And Methods: 52 acromegaly patients (mean age 45.7 ± 1.9 years) and 83 controls (mean age 43.1 ± 2.6 years) were recruited to the study. VDR polymorphism was determined by polymerase chain reaction-based restriction fragment length polymorphism methods.

Results: The distribution of VDR genotypes showed a significant difference in the frequencies of VDR FokI genotypes between patients and controls (P = 0.034). VDR FokI ff genotype was significantly decreased in acromegaly patients (P = 0.035) and carriers of FokI Ff genotype had a 1.5-fold increased risk for acromegaly (OR: 1.5, 95% CI: 1.07-2.1; P = 0.020). IGF1 levels after treatment were significantly higher in patients carrying the Ff genotype compared to carrying ff genotype (P = 0.0049). 25(OH)D3 levels were significantly lower in acromegaly patients (P < 0.001).

Conclusions: Our study suggests that VDR FokI genotypes might affect the development of acromegaly and VDR polymorphisms may play a role in the course of acromegaly as a consequence of altering hormonal status.

Citing Articles

Vitamin D in pituitary driven osteopathies.

Chiloiro S, Costanza F, Riccardi E, Giampietro A, De Marinis L, Bianchi A Pituitary. 2024; 27(6):847-859.

PMID: 39180644 PMC: 11632065. DOI: 10.1007/s11102-024-01439-3.

Gene Polymorphisms and Their Roles in Acromegaly.

Jawiarczyk-Przybylowska A, Kuliczkowska-Plaksej J, Kolackov K, Zembska A, Halupczok-Zyla J, Rolla M Int J Mol Sci. 2023; 24(13).

PMID: 37446150 PMC: 10341435. DOI: 10.3390/ijms241310974.

Characterization of vitamin D metabolism in active acromegaly in the setting of bolus (150,000 IU) cholecalciferol treatment.

Povaliaeva A, Bogdanov V, Zhukov A, Pigarova E, Dzeranova L, Rozhinskaya L Endocrine. 2022; 76(2):407-418.

PMID: 35138562 DOI: 10.1007/s12020-022-02994-0.

Association of Vitamin D Receptor Polymorphisms With Activity of Acromegaly, Vitamin D Status and Risk of Osteoporotic Fractures in Acromegaly Patients.

Jawiarczyk-Przybylowska A, Halupczok-Zyla J, Kolackov K, Gojny L, Zembska A, Bolanowski M Front Endocrinol (Lausanne). 2019; 10:643.

PMID: 31616375 PMC: 6768940. DOI: 10.3389/fendo.2019.00643.

Pre-treatment VD levels and VDR receptors as potential predictors of occurrence and overall survival in paediatric patients with solid tumours-a single institution pilot study.

Bienertova-Vasku J, Drabova K, Zlamal F, Tomandl J, Kyr M, Splichal Z Tumour Biol. 2016; 37(7):9209-19.

PMID: 26768618 DOI: 10.1007/s13277-016-4820-9.

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