Structures of Human DNA Polymerases ν and θ Expose Their End Game

Overview

Journal Nat Struct Mol Biol

Specialties Cell Biology
Molecular Biology

Date 2015 Apr 4

PMID 25837870

Citations 4

Authors

William A Beard

Samuel H Wilson

Affiliations

Soon will be listed here.

Abstract

Although the two B-family human DNA polymerases, pol δ and pol ε, are responsible for the bulk of nuclear genome replication, at least 14 additional polymerases have roles in nuclear DNA repair and replication. In this issue, newly reported crystal structures of two specialized A-family polymerases, pol δ and pol ε, expose these enzymes’ strategies for handling aberrant DNA ends.

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