Distinguishing the Forces Controlling Genetic Variation at the Xdh Locus in Drosophila Pseudoobscura

Overview

Journal Genetics

Publisher Oxford University Press

Specialty Genetics

Date 1989 Oct 1

PMID 2583480

Citations 21

Authors

M A Riley

M E Hallas

R C Lewontin

Affiliations

Soon will be listed here.

Abstract

Fifty-eight isochromosomal lines sampled from two natural populations of Drosophila pseudoobscura in California and one from Bogota, Colombia, were examined using four-cutter restriction mapping. A 4.6-kb region of the xanthine dehydrogenase locus was probed and 66 of 135 restriction sites scored were polymorphic. This predicts that on average every 12th bp would be polymorphic in this region for the genes surveyed if polymorphism occurred randomly along the coding region. In addition, there were 12 insertion/deletion polymorphisms. Forty-nine distinct haplotypes were recognized in the 58 lines examined. The most common haplotype obtained a frequency of only 5%. Measures of base pair heterozygosity (0.0097) and linkage disequilibrium lead to a predicted population size in the range of 1.2-2.4 X 10(6) for the species. High levels of recombination (including gene conversion) can be inferred from the presence of all four gametic types in the data set.

Citing Articles

How chromosomal rearrangements shape adaptation and speciation: Case studies in Drosophila pseudoobscura and its sibling species Drosophila persimilis.

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Genomics of Natural Populations: How Differentially Expressed Genes Shape the Evolution of Chromosomal Inversions in Drosophila pseudoobscura.

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Evidence for stabilizing selection on codon usage in chromosomal rearrangements of Drosophila pseudoobscura.

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Recent selection on the Y-to-dot translocation in Drosophila pseudoobscura.

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Within-niche constant selection of Drosophila inversions?.

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