Preferred SH3 Domain Partners of ADAM Metalloproteases Include Shared and ADAM-specific SH3 Interactions

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2015 Apr 1

PMID 25825872

Citations 13

Authors

Iivari Kleino

Annika Jarviluoma

Jussi Hepojoki

Ari Pekka Huovila

Kalle Saksela

Affiliations

Soon will be listed here.

Abstract

A disintegrin and metalloproteinases (ADAMs) constitute a protein family essential for extracellular signaling and regulation of cell adhesion. Catalytic activity of ADAMs and their predicted potential for Src-homology 3 (SH3) domain binding show a strong correlation. Here we present a comprehensive characterization of SH3 binding capacity and preferences of the catalytically active ADAMs 8, 9, 10, 12, 15, 17, and 19. Our results revealed several novel interactions, and also confirmed many previously reported ones. Many of the identified SH3 interaction partners were shared by several ADAMs, whereas some were ADAM-specific. Most of the ADAM-interacting SH3 proteins were adapter proteins or kinases, typically associated with sorting and endocytosis. Novel SH3 interactions revealed in this study include TOCA1 and CIP4 as preferred partners of ADAM8, and RIMBP1 as a partner of ADAM19. Our results suggest that common as well as distinct mechanisms are involved in regulation and execution of ADAM signaling, and provide a useful framework for addressing the pathways that connect ADAMs to normal and aberrant cell behavior.

Citing Articles

Adam19 Deficiency Impacts Pulmonary Function: Human GWAS Follow-up in a Mouse Knockout Model.

Li H, House J, Nichols C, Gruzdev A, Ward J, Li J Lung. 2024; 202(5):659-672.

PMID: 39153120 PMC: 11427501. DOI: 10.1007/s00408-024-00738-7.

ADAM9 promotes type I interferon-mediated innate immunity during encephalomyocarditis virus infection.

Bazzone L, Zhu J, King M, Liu G, Guo Z, MacKay C Nat Commun. 2024; 15(1):4153.

PMID: 38755212 PMC: 11098812. DOI: 10.1038/s41467-024-48524-6.

Adam19 Deficiency Impacts Pulmonary Function: Human GWAS Follow-up in Mouse.

Li H, House J, Nichols C, Gruzdev A, Ward J, Li J Res Sq. 2024; .

PMID: 38659817 PMC: 11042436. DOI: 10.21203/rs.3.rs-4207678/v1.

ADAM10-a "multitasker" in sepsis: focus on its posttranslational target.

Liao S, Lin Y, Liu L, Yang S, Lin Y, He J Inflamm Res. 2022; 72(3):395-423.

PMID: 36565333 PMC: 9789377. DOI: 10.1007/s00011-022-01673-0.

ADAM8 signaling drives neutrophil migration and ARDS severity.

Conrad C, Yildiz D, Cleary S, Margraf A, Cook L, Schlomann U JCI Insight. 2022; 7(3).

PMID: 35132956 PMC: 8855804. DOI: 10.1172/jci.insight.149870.

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