Functional Lung MRI in Chronic Obstructive Pulmonary Disease: Comparison of T1 Mapping, Oxygen-enhanced T1 Mapping and Dynamic Contrast Enhanced Perfusion

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2015 Mar 31

PMID 25822195

Citations 16

Authors

Bertram J Jobst

Simon M F Triphan

Oliver Sedlaczek

Angela Anjorin

Hans Ulrich Kauczor

Jurgen Biederer

Julia Ley-Zaporozhan

Sebastian Ley

Mark O Wielputz

Affiliations

Soon will be listed here.

Abstract

Purpose: Monitoring of regional lung function in interventional COPD trials requires alternative endpoints beyond global parameters such as FEV1. T1 relaxation times of the lung might allow to draw conclusions on tissue composition, blood volume and oxygen fraction. The aim of this study was to evaluate the potential value of lung Magnetic resonance imaging (MRI) with native and oxygen-enhanced T1 mapping for the assessment of COPD patients in comparison with contrast enhanced perfusion MRI.

Materials And Methods: 20 COPD patients (GOLD I-IV) underwent a coronal 2-dimensional inversion recovery snapshot flash sequence (8 slices/lung) at room air and during inhalation of pure oxygen, as well as dynamic contrast-enhanced first-pass perfusion imaging. Regional distribution of T1 at room air (T1), oxygen-induced T1 shortening (ΔT1) and peak enhancement were rated by 2 chest radiologists in consensus using a semi-quantitative 3-point scale in a zone-based approach.

Results: Abnormal T1 and ΔT1 were highly prevalent in the patient cohort. T1 and ΔT1 correlated positively with perfusion abnormalities (r = 0.81 and r = 0.80; p&0.001), and with each other (r = 0.80; p<0.001). In GOLD stages I and II ΔT1 was normal in 16/29 lung zones with mildly abnormal perfusion (15/16 with abnormal T1). The extent of T1 (r = 0.45; p<0.05), ΔT1 (r = 0.52; p<0.05) and perfusion abnormalities (r = 0.52; p<0.05) showed a moderate correlation with GOLD stage.

Conclusion: Native and oxygen-enhanced T1 mapping correlated with lung perfusion deficits and severity of COPD. Under the assumption that T1 at room air correlates with the regional pulmonary blood pool and that oxygen-enhanced T1 reflects lung ventilation, both techniques in combination are principally suitable to characterize ventilation-perfusion imbalance. This appears valuable for the assessment of regional lung characteristics in COPD trials without administration of i.v. contrast.

Citing Articles

Echo time-dependent observed T1 and quantitative perfusion in chronic obstructive pulmonary disease using magnetic resonance imaging.

Triphan S, Konietzke M, Biederer J, Eichinger M, Vogelmeier C, Jorres R Front Med (Lausanne). 2024; 10:1254003.

PMID: 38249975 PMC: 10797117. DOI: 10.3389/fmed.2023.1254003.

Validation of single reference variable flip angle (SR-VFA) dynamic T mapping with T * correction using a novel rotating phantom.

Malmberg M, Odeen H, Hofstetter L, Hadley J, Parker D Magn Reson Med. 2023; 91(4):1419-1433.

PMID: 38115639 PMC: 10872756. DOI: 10.1002/mrm.29944.

Evaluation of Dynamic Contrast-Enhanced and Oxygen-Enhanced Functional Lung Magnetic Resonance Imaging in Chronic Obstructive Pulmonary Disease Patients.

Srinivas R, Garg M, Debi U, Prabhakar N, Dhooria S, Agarwal R Diagnostics (Basel). 2023; 13(23).

PMID: 38066752 PMC: 10706357. DOI: 10.3390/diagnostics13233511.

[Magnetic resonance imaging of the lung : State of the art].

Wucherpfennig L, Kauczor H, Eichinger M, Wielputz M Radiologie (Heidelb). 2023; 63(11):849-862.

PMID: 37851088 DOI: 10.1007/s00117-023-01229-1.

GOLD stage-specific phenotyping of emphysema and airway disease using quantitative computed tomography.

Konietzke P, Brunner C, Konietzke M, Wagner W, Weinheimer O, Heussel C Front Med (Lausanne). 2023; 10:1184784.

PMID: 37534319 PMC: 10393128. DOI: 10.3389/fmed.2023.1184784.

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