Synthesis and Biological Properties of 5-(1H-1,2,3-triazol-4-yl)isoxazolidines: a New Class of C-nucleosides

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2015 Mar 27

PMID 25812148

Citations 11

Authors

Salvatore V Giofre

Roberto Romeo

Caterina Carnovale

Raffaella Mancuso

Santa Cirmi

Michele Navarra

Adriana Garozzo

Maria A Chiacchio

Affiliations

Soon will be listed here.

Abstract

A novel series of C-nucleosides, featuring the presence of a 1,2,3-triazole ring linked to an isoxazolidine system, has been designed as mimetics of the pyrimidine nucleobases. An antiproliferative effect was observed for compounds 17a and 17b: the growth inhibitory effect reaches the 50% in HepG2 and HT-29 cells and increases up to 56% in the SH-SY5Y cell line after 72 h of incubation at a 100 µM concentration.

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