Vasculitis Secondary to Anti-C1q Antibodies Induced by Toxocariasis

Overview

Journal Infection

Date 2015 Mar 27

PMID 25808264

Citations 7

Authors

Hubert de Boysson

Nicolas Martin Silva

Francois Comoz

Jonathan Boutemy

Boris Bienvenu

Affiliations

Soon will be listed here.

Abstract

Introduction: Vasculitides occurring during parasitic infection are rare and may imply different mechanisms.

Methods: A case report of cutaneous vasculitis and visceral damage during a larva migrans syndrome.

Results: We report the case of a 64-year-old man who developed a purpura along with fever, respiratory failure, abdominal pain and myalgia. Immunological screening showed a high titer of both antinuclear antibodies and anti-double-stranded DNA antibodies along with anti-C1q antibodies. Toxocara canis serology returned highly positive with a positive western-blot. The use of antiparasitic drugs in combination with corticosteroids resulted in a dramatic improvement in the patient's condition.

Conclusions: Clinicians should be aware of the systemic complications that may occur during Toxocara canis infection, including vasculitis and immunological disorder.

Citing Articles

Who Let the Dogs Out? Unmasking the Neglected: A Semi-Systematic Review on the Enduring Impact of Toxocariasis, a Prevalent Zoonotic Infection.

Henke K, Ntovas S, Xourgia E, Exadaktylos A, Klukowska-Rotzler J, Ziaka M Int J Environ Res Public Health. 2023; 20(21).

PMID: 37947530 PMC: 10649795. DOI: 10.3390/ijerph20216972.

Overview of infections as an etiologic factor and complication in patients with vasculitides.

Theofilis P, Vordoni A, Koukoulaki M, Vlachopanos G, Kalaitzidis R Rheumatol Int. 2022; 42(5):759-770.

PMID: 35165771 PMC: 8853270. DOI: 10.1007/s00296-022-05100-9.

Mesenchymal stem cells combined with albendazole as a novel therapeutic approach for experimental neurotoxocariasis.

Beshay E, El-Refai S, Sadek G, Elbadry A, Shalan F, Afifi A Parasitology. 2020; 147(7):799-809.

PMID: 32178741 PMC: 10318261. DOI: 10.1017/S003118202000044X.

The Immunopathology of Complement Proteins and Innate Immunity in Autoimmune Disease.

Defendi F, Thielens N, Clavarino G, Cesbron J, Dumestre-Perard C Clin Rev Allergy Immunol. 2019; 58(2):229-251.

PMID: 31834594 DOI: 10.1007/s12016-019-08774-5.

Clinical utility of anti-C1q antibody in primary and secondary vasculitic conditions.

Jayakanthan K, Gupta A, Mathew J, Ravindran R, Mahasampth G, Danda D Int J Health Sci (Qassim). 2017; 11(5):3-6.

PMID: 29114186 PMC: 5669508.

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