How Close is the Stem Cell Cure to the Alzheimer's Disease: Future and Beyond?

Overview

Journal Neural Regen Res

Date 2015 Mar 26

PMID 25806061

Citations 3

Authors

Jun Tang

Affiliations

Soon will be listed here.

Abstract

Alzheimer's disease, a progressive neurodegenerative illness, is the most common form of dementia. So far, there is neither an effective prevention nor a cure for Alzheimer's disease. In recent decades, stem cell therapy has been one of the most promising treatments for Alzheimer's disease patients. This article aims to summarize the current progress in the stem cell treatments for Alzheimer's disease from an experiment to a clinical research.

Citing Articles

Integrating epigenetic modification and stem cell therapy strategies: A novel approach for advancing Alzheimer's disease treatment - A literature review.

Widaja E, Pawitan J Narra J. 2025; 4(3):e935.

PMID: 39816083 PMC: 11731673. DOI: 10.52225/narra.v4i3.202.

Therapeutic Effects of Human Amniotic Epithelial Stem Cells in a Transgenic Mouse Model of Alzheimer's Disease.

Kim K, Suh Y, Chang K Int J Mol Sci. 2020; 21(7).

PMID: 32290355 PMC: 7178120. DOI: 10.3390/ijms21072658.

Neural stem cell transplantation improves learning and memory by protecting cholinergic neurons and restoring synaptic impairment in an amyloid precursor protein/presenilin 1 transgenic mouse model of Alzheimer's disease.

Zhu Q, Zhang N, Hu N, Jiang R, Lu H, Xuan A Mol Med Rep. 2020; 21(3):1172-1180.

PMID: 31922229 PMC: 7002968. DOI: 10.3892/mmr.2020.10918.

Neurotrophic factor small-molecule mimetics mediated neuroregeneration and synaptic repair: emerging therapeutic modality for Alzheimer's disease.

Kazim S, Iqbal K Mol Neurodegener. 2016; 11(1):50.

PMID: 27400746 PMC: 4940708. DOI: 10.1186/s13024-016-0119-y.

References

Urbach A, Bar-Nur O, Daley G, Benvenisty N . Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells. Cell Stem Cell. 2010; 6(5):407-11. PMC: 3354574. DOI: 10.1016/j.stem.2010.04.005. View

Wenk G . Neuropathologic changes in Alzheimer's disease. J Clin Psychiatry. 2003; 64 Suppl 9:7-10. View

Takahashi K, Yamanaka S . Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006; 126(4):663-76. DOI: 10.1016/j.cell.2006.07.024. View

Burns T, Verfaillie C, Low W . Stem cells for ischemic brain injury: a critical review. J Comp Neurol. 2009; 515(1):125-44. PMC: 4112591. DOI: 10.1002/cne.22038. View

Steinbeck J, Koch P, Derouiche A, Brustle O . Human embryonic stem cell-derived neurons establish region-specific, long-range projections in the adult brain. Cell Mol Life Sci. 2011; 69(3):461-70. PMC: 3256316. DOI: 10.1007/s00018-011-0759-6. View

Bernal G, Peterson D . Neural stem cells as therapeutic agents for age-related brain repair. Aging Cell. 2004; 3(6):345-51. DOI: 10.1111/j.1474-9728.2004.00132.x. View

Panopoulos A, Ruiz S, Izpisua Belmonte J . iPSCs: induced back to controversy. Cell Stem Cell. 2011; 8(4):347-8. DOI: 10.1016/j.stem.2011.03.003. View

Taupin P . Adult neural stem cells, neurogenic niches, and cellular therapy. Stem Cell Rev. 2007; 2(3):213-9. DOI: 10.1007/s12015-006-0049-0. View

Curtis M, Kam M, Faull R . Neurogenesis in humans. Eur J Neurosci. 2011; 33(6):1170-4. DOI: 10.1111/j.1460-9568.2011.07616.x. View

10.

Li B, Piao C, Liu X, Guo W, Xue Y, Duan W . Brain self-protection: the role of endogenous neural progenitor cells in adult brain after cerebral cortical ischemia. Brain Res. 2010; 1327:91-102. DOI: 10.1016/j.brainres.2010.02.030. View

11.

Small G, Bullock R . Defining optimal treatment with cholinesterase inhibitors in Alzheimer's disease. Alzheimers Dement. 2010; 7(2):177-84. DOI: 10.1016/j.jalz.2010.03.016. View

12.

Ryu J, Cho T, Wang Y, McLarnon J . Neural progenitor cells attenuate inflammatory reactivity and neuronal loss in an animal model of inflamed AD brain. J Neuroinflammation. 2009; 6:39. PMC: 2804572. DOI: 10.1186/1742-2094-6-39. View

13.

Moghadam F, Alaie H, Karbalaie K, Tanhaei S, Nasr Esfahani M, Baharvand H . Transplantation of primed or unprimed mouse embryonic stem cell-derived neural precursor cells improves cognitive function in Alzheimerian rats. Differentiation. 2009; 78(2-3):59-68. DOI: 10.1016/j.diff.2009.06.005. View

14.

Shors T, Miesegaes G, Beylin A, Zhao M, Rydel T, Gould E . Neurogenesis in the adult is involved in the formation of trace memories. Nature. 2001; 410(6826):372-6. DOI: 10.1038/35066584. View

15.

Tang J, Xu H, Fan X, Li D, Rancourt D, Zhou G . Embryonic stem cell-derived neural precursor cells improve memory dysfunction in Abeta(1-40) injured rats. Neurosci Res. 2008; 62(2):86-96. DOI: 10.1016/j.neures.2008.06.005. View

16.

Thompson L . Neurodegeneration: a question of balance. Nature. 2008; 452(7188):707-8. DOI: 10.1038/452707a. View

17.

Tang J, Song M, Wang Y, Fan X, Xu H, Bai Y . Noggin and BMP4 co-modulate adult hippocampal neurogenesis in the APP(swe)/PS1(DeltaE9) transgenic mouse model of Alzheimer's disease. Biochem Biophys Res Commun. 2009; 385(3):341-5. DOI: 10.1016/j.bbrc.2009.05.067. View

18.

Stadtfeld M, Hochedlinger K . Induced pluripotency: history, mechanisms, and applications. Genes Dev. 2010; 24(20):2239-63. PMC: 2956203. DOI: 10.1101/gad.1963910. View

19.

Li Z, Gao C, Huang H, Sun W, Yi H, Fan X . Neurotransmitter phenotype differentiation and synapse formation of neural precursors engrafting in amyloid-β(1-40) injured rat hippocampus. J Alzheimers Dis. 2011; 21(4):1233-47. DOI: 10.3233/jad-2010-100003. View

20.

Mucke L . Neuroscience: Alzheimer's disease. Nature. 2009; 461(7266):895-7. DOI: 10.1038/461895a. View