Colonic Sarcoidosis: Unusual Onset of a Systemic Disease

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2015 Mar 26

PMID 25805948

Citations 8

Authors

Paola Erra

Sonia Crusco

Loredana Nugnes

Anna Maria Pollio

Gianni Di Pilla

Giuseppe Biondi

Giovanni Vigliardi

Affiliations

Soon will be listed here.

Abstract

Sarcoidosis is a multisystem chronic inflammatory condition of unknown etiology that has the potential to involve every tissue in the body. Sarcoidosis in the gastrointestinal system, and particularly the colon, is very rare. Here, we report the case of a 57-year-old man with no previous diagnosis of sarcoidosis who presented with new onset of abdominal pain and constipation. A colonoscopy revealed that the abdominal pain was caused by an obstructing lesion in the cecum-ascending colon and lacked a clear histologic diagnosis. Radiologic investigation revealed concentric wall thickening of the cecum-ascending colon with multiple satellite lymphadenopathies, highly suggestive of a malignancy. The patient underwent a laparotomy and a right hemicolectomy was performed. A diagnosis of colonic sarcoidosis was made after the resected specimen was examined. Additionally, a chest computed tomography scan revealed lung involvement with atypical radiologic features in the absence of respiratory symptoms. Only histologic examination of the surgical specimen can yield a diagnosis of gastrointestinal sarcoidosis due to the non-specificity of endoscopic and radiologic findings.

Citing Articles

Gastrointestinal Manifestations of Sarcoidosis: A State-of-the-Art, Comprehensive Review of the Literature-Practical Clinical Insights and Many Unmet Needs on Diagnosis and Treatment.

Nicolosi S, Chernovsky M, Angoni D, Hughes M, Bandini G, McMahan Z Pharmaceuticals (Basel). 2024; 17(9).

PMID: 39338270 PMC: 11435091. DOI: 10.3390/ph17091106.

Colitis and Intestinal Granulomas in Acquired Immunodeficiency Syndrome.

Da Cunha T, Patel S, Vaziri H Clin J Gastroenterol. 2022; 15(4):722-733.

PMID: 35675026 DOI: 10.1007/s12328-022-01640-6.

Diagnosing granulomatous disease during appendectomy.

Senayli A Clin Case Rep. 2021; 9(11):e05074.

PMID: 34815873 PMC: 8593883. DOI: 10.1002/ccr3.5074.

Gastrointestinal sarcoidosis presenting with malabsorption at an early age.

Kalaycik Sengul O, Akkelle B, Volkan B, Tutar E, Celikel C, Ertem D Turk Pediatri Ars. 2021; 55(4):441-444.

PMID: 33414665 PMC: 7750332. DOI: 10.14744/TurkPediatriArs.2019.93274.

CT Findings in Pulmonary and Abdominal Sarcoidosis. Implications for Diagnosis and Classification.

Tana C, Donatiello I, Coppola M, Ricci F, Maccarone M, Ciarambino T J Clin Med. 2020; 9(9).

PMID: 32962242 PMC: 7565100. DOI: 10.3390/jcm9093028.

References

Vahid B, Spodik M, Braun K, Ghazi L, Esmaili A . Sarcoidosis of gastrointestinal tract: a rare disease. Dig Dis Sci. 2007; 52(12):3316-20. DOI: 10.1007/s10620-006-9448-y. View

Lynch 3rd J, Kazerooni E, Gay S . Pulmonary sarcoidosis. Clin Chest Med. 1997; 18(4):755-85. DOI: 10.1016/s0272-5231(05)70417-2. View

AARONSON H, MEIR J, ULIN A . A case of sarcoidosis of the colon. J Albert Einstein Med Cent (Phila). 1957; 6(1):14-6. View

Shimoyama Y, Kusano M, Uchiyama Y, Mori M . Education and Imaging. Gastrointestinal: rectal sarcoidosis due to paralytic ileus resembling adult-onset Hirschsprung disease. J Gastroenterol Hepatol. 2010; 25(8):1464. DOI: 10.1111/j.1440-1746.2010.06423.x. View

Henke C, Henke G, ELVEBACK L, Beard C, Ballard D, Kurland L . The epidemiology of sarcoidosis in Rochester, Minnesota: a population-based study of incidence and survival. Am J Epidemiol. 1986; 123(5):840-5. DOI: 10.1093/oxfordjournals.aje.a114313. View

Bat T, Morgan C, Marx R, Bailey R . Colon sarcoidosis presenting with abdominal pain. Endoscopy. 2014; 46 Suppl 1 UCTN:E121. DOI: 10.1055/s-0034-1364890. View

MacArthur K, Forouhar F, Wu G . Intra-abdominal complications of sarcoidosis. J Formos Med Assoc. 2010; 109(7):484-92. DOI: 10.1016/S0929-6646(10)60082-4. View

Daldoul S, Triki W, El Jeri K, Zaouche A . Unusual presentation of a colonic sarcoidosis. Case Rep Med. 2012; 2012:169760. PMC: 3318266. DOI: 10.1155/2012/169760. View

Maamouri N, Guellouz S, Ben Hariz F, Ketari S, Belkahla N, Ouerghi H . [Gastrointestinal sarcoidosis]. Rev Med Interne. 2010; 31(4):262-7. DOI: 10.1016/j.revmed.2009.12.003. View

10.

. Statement on sarcoidosis. Joint Statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) adopted by the ATS Board of Directors and by.... Am J Respir Crit Care Med. 1999; 160(2):736-55. DOI: 10.1164/ajrccm.160.2.ats4-99. View

11.

Baughman R, Teirstein A, Judson M, Rossman M, Yeager Jr H, Bresnitz E . Clinical characteristics of patients in a case control study of sarcoidosis. Am J Respir Crit Care Med. 2001; 164(10 Pt 1):1885-9. DOI: 10.1164/ajrccm.164.10.2104046. View

12.

Warshauer D, Lee J . Imaging manifestations of abdominal sarcoidosis. AJR Am J Roentgenol. 2003; 182(1):15-28. DOI: 10.2214/ajr.182.1.1820015. View

13.

Kitaichi M . Pathology of pulmonary sarcoidosis. Clin Dermatol. 1986; 4(4):108-15. DOI: 10.1016/0738-081x(86)90039-8. View

14.

Beniwal R, Cummings O, Cho W . Symptomatic gastrointestinal sarcoidosis: case report and review of the literature. Dig Dis Sci. 2003; 48(1):174-8. DOI: 10.1023/a:1021711204498. View

15.

Veitch A, Badger I . Sarcoidosis presenting as colonic polyposis: report of a case. Dis Colon Rectum. 2004; 47(6):937-9. DOI: 10.1007/s10350-004-0520-4. View

16.

Nchimi A, Francotte N, Rausin L, Khamis J . Case 61: ileocecal sarcoidosis. Radiology. 2003; 228(2):452-5. DOI: 10.1148/radiol.2282011952. View

17.

FARMAN J, Ramirez G, RYBAK B, Lebwohl O, Semrad C, Rotterdam H . Gastric sarcoidosis. Abdom Imaging. 1997; 22(3):248-52. DOI: 10.1007/s002619900182. View

18.

Hilzenrat N, Spanier A, Lamoureux E, Bloom C, Sherker A . Colonic obstruction secondary to sarcoidosis: nonsurgical diagnosis and management. Gastroenterology. 1995; 108(5):1556-9. DOI: 10.1016/0016-5085(95)90706-8. View

19.

Esmadi M, Ahmad D, Odum B, Diaz-Arias A, Hammad H . Sarcoidosis: an extremely rare cause of granulomatous enterocolitis. J Gastrointestin Liver Dis. 2012; 21(4):423-5. View

20.

Ushiki A, Koizumi T, Kubo K, Suzawa K, Arakura N, Suzawa H . Colonic sarcoidosis presenting multiple submucosal tumor-like lesions. Intern Med. 2009; 48(20):1813-6. DOI: 10.2169/internalmedicine.48.2427. View