Neurotrophic Factors and Their Effects in the Treatment of Multiple Sclerosis

Overview

Journal Adv Biomed Res

Specialty Biomedical Engineering

Date 2015 Mar 25

PMID 25802822

Citations 33

Authors

Shahnaz Razavi

Ghasemi Nazem

Mohammad Mardani

Ebrahim Esfandiari

Hossein Salehi

Sayyed Hamid Zarkesh Esfahani

Affiliations

Soon will be listed here.

Abstract

Neurotrophins are small molecules of polypeptides, which include nerve growth factor (NGF) family, glial cell line-derived neurotrophic factor (GDNF) family ligands, and neuropoietic cytokines. These factors have an important role in neural regeneration, remyelination, and regulating the development of the peripheral and central nervous systems (PNS and CNS, respectively) by intracellular signaling through specific receptors. It has been suggested that the pathogenesis of human neurodegenerative disorders may be due to an alteration in the neurotrophic factors and their receptors. The use of neurotrophic factors as therapeutic agents is a novel strategy for restoring and maintaining neuronal function during neurodegenerative disorders such as multiple sclerosis. Innate and adaptive immune responses contribute to pathology of neurodegenerative disorders. Furthermore, autoimmune and mesenchymal stem cells, by the release of neurotrophic factors, have the ability to protect neuronal population and can efficiently suppress the formation of new lesions. So, these cells may be an alternative source for delivering neurotrophic factors into the CNS.

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