Health-related Quality of Life in Patients with Primary Cutaneous Amyloidosis

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2015 Mar 24

PMID 25799390

Citations 8

Authors

Sheng Fang

Xiao Shen

Ai-Jun Chen

Shuang Li

Kui Shan

Affiliations

Soon will be listed here.

Abstract

Background: Primary cutaneous amyloidosis (PCA) is a relatively rare and itchy skin disorder characterized by amyloid deposits in the superficial dermis. The cosmetic disfigurement and severe pruritus dramatically affects the patient's quality of life. In spite of the prevalence of the disease in China, the quality of life (QoL) impact of the PCA has not been well defined and is the focus of this study.

Objective: To examine the HRQoL of patients with PCA and to evaluate the association between HRQoL scores, disease, and socio-demographic determinants.

Methods: A total of 104 PCA patients and 101 healthy participants completed the questionnaires. HRQoL was measured using dermatology life quality index (DLQI) and SF-36. The socio demographic and clinical data such as age, sex, duration of disease and distribution of lesion pattern were analyzed mainly by hierarchical multiple regression analyses.

Results: Patients with PCA experienced significantly impaired health-related quality of life. The mean DLQI score was 9.05. Younger age, female gender, more pruritus and distribution pattern were independent predictor correlates of the high DLQI scores. The PCA group showed significantly decreasing average scores in several aspects of psychological symptoms, including SF, RE and MH.

Conclusions: PCA disease has a negative impact on the HRQoL of patients, and the HRQoL is associated with various disease characteristics. In conjunction with medical interventions, psychological and sociocultural assessment and intervention should be an essential part of the management of these cases.

Citing Articles

The evaluation of Congo red staining combined with fluorescence microscopy in the diagnosis of primary cutaneous amyloidosis.

Song H, Cheng Y, Wang X, Hong X, Guo Z, Li H J Dermatol. 2024; 52(2):281-290.

PMID: 39663859 PMC: 11807360. DOI: 10.1111/1346-8138.17562.

Dermatoscopy of primary localised cutaneous amyloidosis - A cross-sectional study in a setting of South Asian public dermatology department.

Pudasaini P, Paudel S, Gc S, Adhikari S, Pudasaini P, Das K Skin Health Dis. 2024; 4(1):e316.

PMID: 38312259 PMC: 10831549. DOI: 10.1002/ski2.316.

Evaluation and comparison of Q-switched Nd: YAG laser 1064 nm and Er: YAG laser 2940 nm in the treatment of macular amyloidosis.

Mokhtari F, Yazdanpanah M, Iraji F, Asilian A, Siadat A, Tavakolifard N Lasers Med Sci. 2024; 39(1):22.

PMID: 38165508 DOI: 10.1007/s10103-023-03965-1.

Primary Localized Cutaneous Amyloidosis in Central Europe: A Retrospective Monocentric Study on Epidemiology and Therapy.

Palla S, Kuroli E, Toth E, Hidvegi B, Hollo P, Medvecz M J Clin Med. 2023; 12(24).

PMID: 38137741 PMC: 10743860. DOI: 10.3390/jcm12247672.

Characterization of Epidermal Function in Individuals with Primary Cutaneous Amyloidosis.

Huang F, Zhang Y, Guo J, Pan H, Liao Z, Yang B Clin Cosmet Investig Dermatol. 2023; 16:3193-3200.

PMID: 37953856 PMC: 10637218. DOI: 10.2147/CCID.S426209.

References

Ferraz L, Almeida F, Vasconcellos M, Faccina A, Ciconelli R, Ferraz M . The impact of lupus erythematosus cutaneous on the Quality of life: the Brazilian-Portuguese version of DLQI. Qual Life Res. 2006; 15(3):565-70. DOI: 10.1007/s11136-005-2638-9. View

Tan T . Epidemiology of primary cutaneous amyloidoses in southeast Asia. Clin Dermatol. 1990; 8(2):20-4. DOI: 10.1016/0738-081x(90)90083-d. View

Wang K, Wang K, Zhang Z . Health-related quality of life and marital quality of vitiligo patients in China. J Eur Acad Dermatol Venereol. 2010; 25(4):429-35. DOI: 10.1111/j.1468-3083.2010.03808.x. View

Mazharinia N, Aghaei S, Shayan Z . Dermatology Life Quality Index (DLQI) scores in burn victims after revival. J Burn Care Res. 2007; 28(2):312-7. DOI: 10.1097/BCR.0B013E318031A151. View

Wright A, Wijeratne A, Hung T, Gao W, Whittaker S, Morris S . Prevalence and severity of pruritus and quality of life in patients with cutaneous T-cell lymphoma. J Pain Symptom Manage. 2012; 45(1):114-9. DOI: 10.1016/j.jpainsymman.2012.01.012. View

Williamson D, Gonzalez M, Finlay A . The effect of hair loss on quality of life. J Eur Acad Dermatol Venereol. 2001; 15(2):137-9. DOI: 10.1046/j.1468-3083.2001.00229.x. View

Wang X, Zhao T, Zhang X . [Assessment on the reliability and validity of the Dermatology Life Quality Index in Chinese version]. Zhonghua Liu Xing Bing Xue Za Zhi. 2004; 25(9):791-3. View

Zachariae R, Zachariae H, Blomqvist K, Davidsson S, Molin L, Mork C . Quality of life in 6497 Nordic patients with psoriasis. Br J Dermatol. 2002; 146(6):1006-16. DOI: 10.1046/j.1365-2133.2002.04742.x. View

Basra M, Fenech R, Gatt R, Salek M, Finlay A . The Dermatology Life Quality Index 1994-2007: a comprehensive review of validation data and clinical results. Br J Dermatol. 2008; 159(5):997-1035. DOI: 10.1111/j.1365-2133.2008.08832.x. View

10.

Ware Jr J, Sherbourne C . The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992; 30(6):473-83. View

11.

Li L, Wang H, Shen Y . Chinese SF-36 Health Survey: translation, cultural adaptation, validation, and normalisation. J Epidemiol Community Health. 2003; 57(4):259-63. PMC: 1732425. DOI: 10.1136/jech.57.4.259. View

12.

Nakjang Y, Sivayathorn A, Reungsinpinya S, Yutthanawiwat T . Biphasic amyloidosis: a clinicopathological and histochemical study. Australas J Dermatol. 1982; 23(2):82-6. DOI: 10.1111/j.1440-0960.1982.tb00607.x. View

13.

Gupta M, Gupta A . Depression and suicidal ideation in dermatology patients with acne, alopecia areata, atopic dermatitis and psoriasis. Br J Dermatol. 1999; 139(5):846-50. DOI: 10.1046/j.1365-2133.1998.02511.x. View

14.

Ghajarzadeh M, Ghiasi M, Kheirkhah S . Associations between skin diseases and quality of life: a comparison of psoriasis, vitiligo, and alopecia areata. Acta Med Iran. 2012; 50(7):511-5. View

15.

Gelfand J, Feldman S, Stern R, Thomas J, Rolstad T, Margolis D . Determinants of quality of life in patients with psoriasis: a study from the US population. J Am Acad Dermatol. 2004; 51(5):704-8. DOI: 10.1016/j.jaad.2004.04.014. View

16.

Horn H, Tidman M . Quality of life in epidermolysis bullosa. Clin Exp Dermatol. 2002; 27(8):707-10. DOI: 10.1046/j.1365-2230.2002.01121.x. View

17.

Kanikowska A, Kramer L, Pawlaczyk M . Quality of life in Polish patients with psoriasis. J Eur Acad Dermatol Venereol. 2008; 23(1):92-3. DOI: 10.1111/j.1468-3083.2008.02712.x. View

18.

Phan N, Blome C, Fritz F, Gerss J, Reich A, Ebata T . Assessment of pruritus intensity: prospective study on validity and reliability of the visual analogue scale, numerical rating scale and verbal rating scale in 471 patients with chronic pruritus. Acta Derm Venereol. 2011; 92(5):502-7. DOI: 10.2340/00015555-1246. View

19.

Harris A, Burge S, Dykes P, Finlay A . Handicap in Darier's disease and Hailey-Hailey disease. Br J Dermatol. 1996; 135(6):959-63. DOI: 10.1046/j.1365-2133.1996.d01-1102.x. View

20.

Finlay A, Khan G . Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use. Clin Exp Dermatol. 1994; 19(3):210-6. DOI: 10.1111/j.1365-2230.1994.tb01167.x. View