Clinicopathological Aspects of Patients with Recurrence of Borderline Ovarian Tumors

Overview

Journal Obstet Gynecol Sci

Specialty Gynecology & Obstetrics

Date 2015 Mar 24

PMID 25798422

Citations 8

Authors

Sumin Oh

Ran Kim

Yoo-Kyung Lee

Jae Weon Kim

Noh-Hyun Park

Yong-Sang Song

Affiliations

Soon will be listed here.

Abstract

Objective: Despite the good prognosis of borderline ovarian tumors (BOTs), a few BOT patients experience the relapse of disease, either borderline or malignant. However, the risk of recurrence of BOTs is somewhat controversial. We intended to find out the specific characteristics and prognosis of the recurrence of BOTs.

Methods: Between 1995 and 2012, 130 women were diagnosed with BOTs at a single institution. Eleven patients diagnosed and treated for the recurrence of BOTs including seven cancerous and four borderline relapses were included for the analysis in this retrospective study. Clinicopathological characteristics and surgical procedures as well as follow-up data with overall survival were assessed. Statistical analyses was performed using the χ(2) test, t-test and log-rank test with Cox regression.

Results: One hundred and thirty patients with mean follow-up of 65.8 months were evaluated, of whom half were below 40 years old at their first diagnosis of BOTs. Among 11 recurrent cases (8.5%), 7 cancerous transformations (5.4%) and 4 borderline recurrences (3.1%) were detected with median time of 6 and 71 months after the primary surgery, respectively. Nine out of 11 recurrences were happened at their equal or below 40-years-old age at the primary diagnosis (P=0.027). Also, all 7 cancerous relapses arose from premenopausal women of median age of 35 years old. Twenty (15%) patients had laparoscopic surgery and they were all treated conservatively. Among those 20, 5 were suffered from relapse of BOTs and laparoscopic approach was proved to be a significant risk factor for disease relapse in our study (P=0.013). Although laparoscopic surgery was revealed had meaningful influence on disease free survival (P=0.024), it was not significant on overall survival (P=0.226).

Conclusion: Laparoscopic conservative surgery for BOTs can be accepted under close follow-ups. And younger patients should be followed for long period to evaluate recurrence.

Citing Articles

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Identifying Borderline Ovarian Tumor Recurrence Using Routine Ultrasound Follow-Up.

Lazurko C, Feigenberg T, Murphy J, Pulman K, Lennox G, Dube V Cancers (Basel). 2023; 15(1).

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Diagnostic accuracy of frozen section analysis of borderline ovarian tumors: a meta-analysis with emphasis on misdiagnosis factors.

Huang Z, Li L, Li C, Ngaujah S, Yao S, Chu R J Cancer. 2018; 9(16):2817-2824.

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The safety of fertility and ipsilateral ovary procedures for borderline ovarian tumors.

Lou T, Yuan F, Feng Y, Wang S, Bai H, Zhang Z Oncotarget. 2018; 8(70):115718-115729.

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Borderline tumors of the ovary: A clinicopathological study.

Yasmeen S, Hannan A, Sheikh F, Syed A, Siddiqui N Pak J Med Sci. 2017; 33(2):369-373.

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