Signal Mechanisms of Phototransduction in Retinal Rod

The levels of intracellular molecules are modulated by illumination of rod photoreceptor cells in the vertebrate retina. Among these are Ca ions, cyclic nucleotides (cGMP in particular), and phosphate nucleotides (ATP and GTP). It is presumed now that at least two of these molecules, Ca and cGMP, may function as chemical linkers between the absorption of light by rhodopsin and the ionic channels of the plasma membrane of the rod outer segment that close when the rod is illuminated. The manuscript will review the physiology of the rod cell, the evidence in support of light-dependent changes in the intracellular levels of various small molecules, and the role of these changes in coupling rhodopsin excitation to the control of the light-sensitive membrane channels in the rod.