Bleomycin and Misonidazole Cytotoxicity

Overview

Journal Br J Cancer

Specialty Oncology

Date 1985 Apr 1

PMID 2579666

Citations 2

Authors

M Korbelik

B Palcic

L D SKARSGARD

Affiliations

Soon will be listed here.

Abstract

Chinese hamster ovary (CHO) cells were exposed in vitro to combinations of bleomycin and misonidazole under hypoxic conditions. Only one drug was present at any given time and cells were washed before being exposed to the second drug. Both drugs induced potentially lethal damage (PLD). This damage was repaired under hypoxic conditions very rapidly, and bleomycin-induced PLD was repaired more rapidly than misonidazole-induced PLD. If, after the combined treatment, cells are kept in hypoxia, much of the damage can be repaired.

Citing Articles

Platinum-dye complexes inhibit repair of potentially lethal damage following bleomycin treatment.

Wang Y, Herman T, Teicher B Br J Cancer. 1989; 59(5):722-6.

PMID: 2472165 PMC: 2247223. DOI: 10.1038/bjc.1989.152.

Platinum complexes inhibit repair of potentially lethal damage following bleomycin treatment.

Holden S, Teicher B, Boeheim K, Weichselbaum R, Ervin T Br J Cancer. 1987; 55(3):245-8.

PMID: 2436643 PMC: 2001757. DOI: 10.1038/bjc.1987.47.

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