Mitofusin-2 Over-expresses and Leads to Dysregulation of Cell Cycle and Cell Invasion in Lung Adenocarcinoma

Overview

Journal Med Oncol

Publisher Springer

Specialty Oncology

Date 2015 Mar 23

PMID 25796500

Citations 34

Authors

Yuqing Lou

Rong Li

Jielin Liu

Yanwei Zhang

Xueyan Zhang

Bo Jin

Ya Liu

Zuoguang Wang

Hua Zhong

Shaojun Wen

Baohui Han

Affiliations

Soon will be listed here.

Abstract

Mitofusin-2 (MFN2) is a mitochondrial protein associated with mitochondrial fusion process. It was initially identified as a hyperplasia suppressor and implicated in Charcot-Marie-Tooth disease. Recent studies showed that MFN2 played important roles in the development of multiple tumors. Here we examined MFN2 expression in 30 lung adenocarcinoma samples and revealed that the expression of MFN2 was significantly higher in lung adenocarcinoma tissues as compared to adjacent normal tissues. We then investigated the impact of MFN2 knockdown on A549 human lung adenocarcinoma cells and showed that cell proliferation, cell cycle and invasion behavior were all deregulated by MFN2 knockdown. And deregulation of cell cycle pathway after MFN2 knockdown was confirmed by microarray analysis. Furthermore, microarray analysis also revealed that different oncogenes such as RAP1A, RALB and ITGA2 were oppositely regulated by MFN2, which provided molecular clues for the paradoxical functions of MFN2 in tumor development. Taken together, our study unraveled the tumor-promoting functions of MFN2 in lung adenocarcinoma and implicated that the role of MFN2 in cancer development might be more complicated than expected and should be explored in detail in the future.

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