P-selectin Plasma Levels and Genetic Variant Associated With Diabetic Retinopathy in African Americans

Overview

Journal Am J Ophthalmol

Specialty Ophthalmology

Date 2015 Mar 22

PMID 25794792

Citations 17

Authors

Alan Penman

Suzanne Hoadley

James G Wilson

Herman A Taylor

Ching J Chen

Lucia Sobrin

Affiliations

Soon will be listed here.

Abstract

Purpose: To report the prevalence and risk factors for retinopathy in African Americans with impaired fasting glucose (IFG) and type 2 diabetes in the Jackson Heart Study and to determine if P-selectin plasma levels are independently associated with retinopathy in this population.

Design: Prospective, cross-sectional observational study.

Methods: setting: Community-based epidemiologic study.

Study Population: Total of 629 patients with type 2 diabetes and 266 participants with impaired fasting glucose.

Observation Procedures: Bilateral, 7-field fundus photographs were scored by masked readers for diabetic retinopathy (DR) level. Covariate data including P-selectin plasma levels and genotypes were collected in a standardized fashion.

Main Outcome Measures: Association between risk factors, including P-selectin plasma levels and genotypes, and retinopathy.

Results: The prevalences of any retinopathy among participants with IFG and type 2 diabetes were 9.4% and 32.4%, respectively. Among those with type 2 diabetes, in multivariate models adjusted for age, sex, and other traditional risk factors, higher P-selectin levels were associated with any DR (odds ratio = 1.11, 95% confidence interval = 1.02-1.21, P = .02) and proliferative DR (odds ratio = 1.23, 95% confidence interval = 1.03-1.46, P = .02). To further investigate the relationship between P-selectin and DR, we examined the association between P-selectin genotype and DR. Minor allele homozygotes for the variant rs6128 were less likely to develop DR (P after Bonferroni correction = 0.03).

Conclusions: Both serologic and genetic data show an association between P-selectin and DR in the Jackson Heart Study. If confirmed in other studies, this association may provide insight into the pathogenesis of retinopathy.

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References

Munoz B, West S, Rubin G, Schein O, Quigley H, Bressler S . Causes of blindness and visual impairment in a population of older Americans: The Salisbury Eye Evaluation Study. Arch Ophthalmol. 2000; 118(6):819-25. DOI: 10.1001/archopht.118.6.819. View

Hutchinson A, McIntosh A, Peters J, OKeeffe C, Khunti K, Baker R . Effectiveness of screening and monitoring tests for diabetic retinopathy--a systematic review. Diabet Med. 2000; 17(7):495-506. DOI: 10.1046/j.1464-5491.2000.00250.x. View

Ridker P, Buring J, Rifai N . Soluble P-selectin and the risk of future cardiovascular events. Circulation. 2001; 103(4):491-5. DOI: 10.1161/01.cir.103.4.491. View

Stratton I, Kohner E, Aldington S, Turner R, Holman R, Manley S . UKPDS 50: risk factors for incidence and progression of retinopathy in Type II diabetes over 6 years from diagnosis. Diabetologia. 2001; 44(2):156-63. DOI: 10.1007/s001250051594. View

Klein R, Marino E, Kuller L, Polak J, Tracy R, Gottdiener J . The relation of atherosclerotic cardiovascular disease to retinopathy in people with diabetes in the Cardiovascular Health Study. Br J Ophthalmol. 2002; 86(1):84-90. PMC: 1770969. DOI: 10.1136/bjo.86.1.84. View

Klein R, Sharrett A, Klein B, Moss S, Folsom A, Wong T . The association of atherosclerosis, vascular risk factors, and retinopathy in adults with diabetes : the atherosclerosis risk in communities study. Ophthalmology. 2002; 109(7):1225-34. DOI: 10.1016/s0161-6420(02)01074-6. View

van Leiden H, Dekker J, Moll A, Nijpels G, Heine R, Bouter L . Risk factors for incident retinopathy in a diabetic and nondiabetic population: the Hoorn study. Arch Ophthalmol. 2003; 121(2):245-51. DOI: 10.1001/archopht.121.2.245. View

Baker R . Diabetic retinopathy in African Americans: vision impairment, prevalence, incidence, and risk factors. Int Ophthalmol Clin. 2003; 43(4):105-22. DOI: 10.1097/00004397-200343040-00011. View

Williams G, Scott I, Haller J, Maguire A, Marcus D, McDonald H . Single-field fundus photography for diabetic retinopathy screening: a report by the American Academy of Ophthalmology. Ophthalmology. 2004; 111(5):1055-62. DOI: 10.1016/j.ophtha.2004.02.004. View

10.

. Grading diabetic retinopathy from stereoscopic color fundus photographs--an extension of the modified Airlie House classification. ETDRS report number 10. Early Treatment Diabetic Retinopathy Study Research Group. Ophthalmology. 1991; 98(5 Suppl):786-806. View

11.

Klein B, Moss S, Klein R, Surawicz T . The Wisconsin Epidemiologic Study of Diabetic Retinopathy. XIII. Relationship of serum cholesterol to retinopathy and hard exudate. Ophthalmology. 1991; 98(8):1261-5. DOI: 10.1016/s0161-6420(91)32145-6. View

12.

Klein R, Klein B, Moss S, Linton K . The Beaver Dam Eye Study. Retinopathy in adults with newly discovered and previously diagnosed diabetes mellitus. Ophthalmology. 1992; 99(1):58-62. DOI: 10.1016/s0161-6420(92)32011-1. View

13.

Pugh J, Jacobson J, van Heuven W, Watters J, Tuley M, Lairson D . Screening for diabetic retinopathy. The wide-angle retinal camera. Diabetes Care. 1993; 16(6):889-95. DOI: 10.2337/diacare.16.6.889. View

14.

Limb G, CHIGNELL A, Green W, Leroy F, Dumonde D . Distribution of TNF alpha and its reactive vascular adhesion molecules in fibrovascular membranes of proliferative diabetic retinopathy. Br J Ophthalmol. 1996; 80(2):168-73. PMC: 505411. DOI: 10.1136/bjo.80.2.168. View

15.

Chew E, Klein M, Ferris 3rd F, Remaley N, Murphy R, Chantry K . Association of elevated serum lipid levels with retinal hard exudate in diabetic retinopathy. Early Treatment Diabetic Retinopathy Study (ETDRS) Report 22. Arch Ophthalmol. 1996; 114(9):1079-84. DOI: 10.1001/archopht.1996.01100140281004. View

16.

Davis M, Fisher M, Gangnon R, Barton F, Aiello L, Chew E . Risk factors for high-risk proliferative diabetic retinopathy and severe visual loss: Early Treatment Diabetic Retinopathy Study Report #18. Invest Ophthalmol Vis Sci. 1998; 39(2):233-52. View

17.

Lunetta M, Infantone L, Calogero A, Infantone E . Increased urinary albumin excretion is a marker of risk for retinopathy and coronary heart disease in patients with type 2 diabetes mellitus. Diabetes Res Clin Pract. 1998; 40(1):45-51. DOI: 10.1016/s0168-8227(98)00024-2. View

18.

Lip P, Jones A, Price N, Headon M, Beevers D, Lip G . Do intraocular angiotensin II levels, plasma prothrombotic factors and endothelial dysfunction contribute to proliferative diabetic retinopathy?. Acta Ophthalmol Scand. 1998; 76(5):533-6. DOI: 10.1034/j.1600-0420.1998.760504.x. View

19.

Emanuele N, Sacks J, Klein R, Reda D, Anderson R, Duckworth W . Ethnicity, race, and baseline retinopathy correlates in the veterans affairs diabetes trial. Diabetes Care. 2005; 28(8):1954-8. DOI: 10.2337/diacare.28.8.1954. View

20.

Taylor Jr H, Wilson J, Jones D, Sarpong D, Srinivasan A, Garrison R . Toward resolution of cardiovascular health disparities in African Americans: design and methods of the Jackson Heart Study. Ethn Dis. 2005; 15(4 Suppl 6):S6-4-17. View