Assessment of Four Experimental Models of Hyperlipidemia

Overview

Journal Lab Anim (NY)

Date 2015 Mar 21

PMID 25793679

Citations 4

Authors

Yisel Gonzalez Madariaga

Maria Boffill Cardenas

Maibia Tamayo Irsula

Orestes Castillo Alfonso

Bennia Alfonso Caceres

Emoe Betancourt Morgado

Affiliations

Soon will be listed here.

Abstract

Various animal models of hyperlipidemia are used in research. Four rodent hyperlipidemia experimental models are examined in this study: three chronic hyperlipidemia models based on dietary supplementation with lipid or sucrose for 3 months and one acute hyperlipidemia model based on administration of the nonionic surfactant poloxamer. Neither lipid supplementation nor sucrose supplementation in Wistar rats was effective for establishing hyperlipidemia. Combining both lipid and sucrose supplementation in BALB/c mice induced hypercholesterolemia, as reflected in a considerable increase in blood cholesterol concentration, but did not produce an increase in blood triglyceride concentration. Poloxamer administration in C57BL/J6 mice produced increases in blood cholesterol and triglyceride concentrations. The authors conclude that supplementation of both lipid and sucrose in BALB/c mice was the most effective method for developing chronic hypercholesterolemia.

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