Pharmacological Analyses of Learning and Memory in Zebrafish (Danio Rerio)

Overview

Journal Pharmacol Biochem Behav

Publisher Elsevier

Specialties Biochemistry
Pharmacology
Psychology
Social Sciences

Date 2015 Mar 21

PMID 25792292

Citations 14

Authors

Jordan M Bailey

Anthony N Oliveri

Edward D Levin

Affiliations

Soon will be listed here.

Abstract

Over the last decade, zebrafish (Danio rerio) have become valuable as a complementary model in behavioral pharmacology, opening a new avenue for understanding the relationships between drug action and behavior. This species offers a useful intermediate approach bridging the gap between in vitro studies and traditional mammalian models. Zebrafish offer great advantages of economy compared to their rodent counterparts, their complex brains and behavioral repertoire offer great translational potential relative to in vitro models. The development and validation of a variety of tests to measure behavior, including cognition, in zebrafish have set the stage for the use of this animal for behavioral pharmacology studies. This has led to research into the basic mechanisms of cognitive function as well as screening for potential cognition-improving drug therapies, among other lines of research. As with all models, zebrafish have limitations, which span pharmacokinetic challenges to difficulties quantifying behavior. The use, efficacy and limitations associated with a zebrafish model of cognitive function are discussed in this review, within the context of behavioral pharmacology.

Citing Articles

Zebrafish as a Potential Model for Neurodegenerative Diseases: A Focus on Toxic Metals Implications.

Paduraru E, Iacob D, Rarinca V, Plavan G, Ureche D, Jijie R Int J Mol Sci. 2023; 24(4).

PMID: 36834835 PMC: 9959844. DOI: 10.3390/ijms24043428.

Dopamine Release Impairments Accompany Locomotor and Cognitive Deficiencies in Rotenone-Treated Parkinson's Disease Model Zebrafish.

Hettiarachchi P, Niyangoda S, Jarosova R, Johnson M Chem Res Toxicol. 2022; 35(11):1974-1982.

PMID: 36178476 PMC: 10127151. DOI: 10.1021/acs.chemrestox.2c00150.

Exposure to leucine alters glutamate levels and leads to memory and social impairment in zebrafish.

da Silva Lemos I, Wessler L, Duarte M, da Silva G, Bernardo H, Candiotto G Metab Brain Dis. 2022; 37(8):2925-2935.

PMID: 36040712 DOI: 10.1007/s11011-022-01070-w.

The Brilliance of the Zebrafish Model: Perception on Behavior and Alzheimer's Disease.

Shenoy A, Banerjee M, Upadhya A, Bagwe-Parab S, Kaur G Front Behav Neurosci. 2022; 16:861155.

PMID: 35769627 PMC: 9234549. DOI: 10.3389/fnbeh.2022.861155.

Zebrafish models of fetal alcohol spectrum disorders.

Fernandes Y, Lovely C Genesis. 2021; 59(11):e23460.

PMID: 34739740 PMC: 9014963. DOI: 10.1002/dvg.23460.

References

van der Staay F, Gieling E, Espitia Pinzon N, Nordquist R, Ohl F . The appetitively motivated "cognitive" holeboard: a family of complex spatial discrimination tasks for assessing learning and memory. Neurosci Biobehav Rev. 2011; 36(1):379-403. DOI: 10.1016/j.neubiorev.2011.07.008. View

Panula P, Sallinen V, Sundvik M, Kolehmainen J, Torkko V, Tiittula A . Modulatory neurotransmitter systems and behavior: towards zebrafish models of neurodegenerative diseases. Zebrafish. 2008; 3(2):235-47. DOI: 10.1089/zeb.2006.3.235. View

Jesuthasan S . Fear, anxiety, and control in the zebrafish. Dev Neurobiol. 2012; 72(3):395-403. DOI: 10.1002/dneu.20873. View

Kim Y, Lee Y, Kim D, Jung M, Lee C . Scopolamine-induced learning impairment reversed by physostigmine in zebrafish. Neurosci Res. 2010; 67(2):156-61. DOI: 10.1016/j.neures.2010.03.003. View

Mathur P, Lau B, Guo S . Conditioned place preference behavior in zebrafish. Nat Protoc. 2011; 6(3):338-45. PMC: 6233885. DOI: 10.1038/nprot.2010.201. View

Ruhl T, Prinz N, Oellers N, Seidel N, Jonas A, Albayram O . Acute administration of THC impairs spatial but not associative memory function in zebrafish. Psychopharmacology (Berl). 2014; 231(19):3829-42. DOI: 10.1007/s00213-014-3522-5. View

Echevarria D, Jouandot D, Toms C . Assessing attention in the zebrafish: Are we there yet?. Prog Neuropsychopharmacol Biol Psychiatry. 2011; 35(6):1416-20. DOI: 10.1016/j.pnpbp.2011.01.020. View

Antunes M, Biala G . The novel object recognition memory: neurobiology, test procedure, and its modifications. Cogn Process. 2011; 13(2):93-110. PMC: 3332351. DOI: 10.1007/s10339-011-0430-z. View

Chacon D, Luchiari A . A dose for the wiser is enough: the alcohol benefits for associative learning in zebrafish. Prog Neuropsychopharmacol Biol Psychiatry. 2014; 53:109-15. DOI: 10.1016/j.pnpbp.2014.03.009. View

10.

Parker M, Millington M, Combe F, Brennan C . Development and implementation of a three-choice serial reaction time task for zebrafish (Danio rerio). Behav Brain Res. 2011; 227(1):73-80. PMC: 4167591. DOI: 10.1016/j.bbr.2011.10.037. View

11.

Castellano C, Cestari V, Ciamei A . NMDA receptors and learning and memory processes. Curr Drug Targets. 2001; 2(3):273-83. DOI: 10.2174/1389450013348515. View

12.

Merchant H, Luciana M, Hooper C, Majestic S, Tuite P . Interval timing and Parkinson's disease: heterogeneity in temporal performance. Exp Brain Res. 2007; 184(2):233-48. DOI: 10.1007/s00221-007-1097-7. View

13.

Bardo M, Bevins R . Conditioned place preference: what does it add to our preclinical understanding of drug reward?. Psychopharmacology (Berl). 2001; 153(1):31-43. DOI: 10.1007/s002130000569. View

14.

Grossman L, Utterback E, Stewart A, Gaikwad S, Chung K, Suciu C . Characterization of behavioral and endocrine effects of LSD on zebrafish. Behav Brain Res. 2010; 214(2):277-84. DOI: 10.1016/j.bbr.2010.05.039. View

15.

Collier A, Echevarria D . The utility of the zebrafish model in conditioned place preference to assess the rewarding effects of drugs. Behav Pharmacol. 2013; 24(5-6):375-83. DOI: 10.1097/FBP.0b013e328363d14a. View

16.

Levin E, Sledge D, Roach S, Petro A, Donerly S, Linney E . Persistent behavioral impairment caused by embryonic methylphenidate exposure in zebrafish. Neurotoxicol Teratol. 2011; 33(6):668-73. PMC: 3225500. DOI: 10.1016/j.ntt.2011.06.004. View

17.

Ali S, Champagne D, Spaink H, Richardson M . Zebrafish embryos and larvae: a new generation of disease models and drug screens. Birth Defects Res C Embryo Today. 2011; 93(2):115-33. DOI: 10.1002/bdrc.20206. View

18.

Colwill R, Raymond M, Ferreira L, Escudero H . Visual discrimination learning in zebrafish (Danio rerio). Behav Processes. 2005; 70(1):19-31. DOI: 10.1016/j.beproc.2005.03.001. View

19.

Bailey J, Johnson J, Newland M . Mechanisms and performance measures in mastery-based incremental repeated acquisition: behavioral and pharmacological analyses. Psychopharmacology (Berl). 2010; 209(4):331-41. DOI: 10.1007/s00213-010-1801-3. View

20.

Gerlai R . Associative learning in zebrafish (Danio rerio). Methods Cell Biol. 2011; 101:249-70. DOI: 10.1016/B978-0-12-387036-0.00012-8. View