Clinicopathologic Features of Chronic Nonspecific Multiple Ulcers of the Small Intestine

Overview

Journal Clin J Gastroenterol

Specialty Gastroenterology

Date 2015 Mar 20

PMID 25788296

Citations 18

Authors

Motohiro Esaki

Junji Umeno

Takanari Kitazono

Takayuki Matsumoto

Affiliations

Soon will be listed here.

Abstract

Chronic nonspecific multiple ulcers of the small intestine is a rare but distinct clinical condition, characterized by multiple small intestinal ulcers of nonspecific histology and chronic, persistent gastrointestinal bleeding without nonsteroidal anti-inflammatory drug use. However, because of the term "nonspecific" in its nomenclature, some gastroenterologists have misinterpreted the disease as the condition with small intestinal ulcers caused by undetermined etiologies without considering clinical features. Such misinterpretation has led to the heterogeneity of clinicopathologic features of the disease, as well as to ambiguity regarding a possible genetic contribution. It thus seems necessary to recognize the clinical entity of the disease precisely to avoid misinterpretation. In this review, we describe the clinicopathologic features, differential diagnosis, and the possibility of a genetic contribution to the disease.

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