Potential of Gd-EOB-DTPA-enhanced MR Imaging for Evaluation of Bile Duct Ligation-induced Liver Injury in Rabbits

Overview

Journal Hepatol Int

Publisher Springer

Specialty Gastroenterology

Date 2015 Mar 20

PMID 25788184

Citations 1

Authors

Ying Ding

Sheng-Xiang Rao

Caizhong Chen

Renchen Li

Meng-Su Zeng

Affiliations

Soon will be listed here.

Abstract

Objectives: The aim of this study was to evaluate the potential of gadoxetic acid (Gd-EOB-DTPA)-enhanced MRI for assessment of bile duct ligation (BDL)-induced chelostatic liver injury in an animal model by T1 relaxation time measurements and first-pass perfusion analyses.

Materials And Methods: Twenty-four rabbits were classified into three groups as follows: control group (N group), n = 8; BDL group studied on the 5th postoperative day (BDL-5d group), n = 8; BDL group studied on the 14th postoperative day (BDL-14d group), n = 8. A dual flip angle three-dimensional gradient echo sequence with volumetric interpolated breath-hold examination was performed before and at 20 min [hepatobiliary phase (HBP)] after Gd-EOB-DTPA administration. Besides, early dynamic contrast-enhanced MRI was performed for 4.32 min with a temporal resolution of 2.2 s. T1 relaxation times of liver parenchyma were measured and perfusion parameters were calculated.

Results: Dilatation of intra-hepatic bile duct was found only in the BDL-14d group. HBP T1 relaxation times of the BDL-5d and BDL-14d groups were significantly prolonged (p < 0.001) and the enhancement slope percentage of BDL-5d and BDL-14d groups were significantly lowered in comparison with that of the N group (p < 0.001). There were no differences between the BDL-5d group and the BDL-14d group for HBP T1 relaxation times and the enhancement slope percentage (p > 0.05). Area under the receiver operating characteristic curve of HBP T1 relaxation time and the enhancement slope percentage for the selection of chelostatic liver were 0.98 and 0.92 for the BDL-5d group, and 0.96 and 0.98 for the BDL-14d group, respectively.

Conclusions: HBP T1 relaxation time measurement in combination with first-pass enhancement slope percentage withhold promise to assess extrahepatic chelostatic liver injury.

Citing Articles

Gadoxetic acid-enhanced magnetic resonance imaging in the assessment of hepatic sinusoidal obstruction syndrome in a mouse model.

Chen Y, Yang L, Li J, Rao S, Ding Y, Zeng M World J Hepatol. 2024; 16(8):1167-1176.

PMID: 39221094 PMC: 11362905. DOI: 10.4254/wjh.v16.i8.1167.

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