Aurora B Prevents Chromosome Arm Separation Defects by Promoting Telomere Dispersion and Disjunction

Overview

Journal J Cell Biol

Specialty Cell Biology

Date 2015 Mar 18

PMID 25778919

Citations 13

Authors

Celine Reyes

Celine Serrurier

Tiphaine Gauthier

Yannick Gachet

Sylvie Tournier

Affiliations

Soon will be listed here.

Abstract

The segregation of centromeres and telomeres at mitosis is coordinated at multiple levels to prevent the formation of aneuploid cells, a phenotype frequently observed in cancer. Mitotic instability arises from chromosome segregation defects, giving rise to chromatin bridges at anaphase. Most of these defects are corrected before anaphase onset by a mechanism involving Aurora B kinase, a key regulator of mitosis in a wide range of organisms. Here, we describe a new role for Aurora B in telomere dispersion and disjunction during fission yeast mitosis. Telomere dispersion initiates in metaphase, whereas disjunction takes place in anaphase. Dispersion is promoted by the dissociation of Swi6/HP1 and cohesin Rad21 from telomeres, whereas disjunction occurs at anaphase after the phosphorylation of condensin subunit Cnd2. Strikingly, we demonstrate that deletion of Ccq1, a telomeric shelterin component, rescued cell death after Aurora inhibition by promoting the loading of condensin on chromosome arms. Our findings reveal an essential role for telomeres in chromosome arm segregation.

Citing Articles

Phosphorylation of Bub1 by Mph1 promotes Bub1 signaling at the kinetochore to ensure accurate chromosome segregation.

Jian Y, Jiang Y, Nie L, Dou Z, Liu X, Fu C J Biol Chem. 2023; 300(1):105559.

PMID: 38097187 PMC: 10805674. DOI: 10.1016/j.jbc.2023.105559.

Condensin positioning at telomeres by shelterin proteins drives sister-telomere disjunction in anaphase.

Colin L, Reyes C, Berthezene J, Maestroni L, Modolo L, Toselli E Elife. 2023; 12.

PMID: 37988290 PMC: 10662949. DOI: 10.7554/eLife.89812.

Global phosphoproteomic analysis identified key kinases regulating male meiosis in mouse.

Li H, Chen H, Zhang X, Qi Y, Wang B, Cui Y Cell Mol Life Sci. 2022; 79(8):467.

PMID: 35930080 PMC: 11071816. DOI: 10.1007/s00018-022-04507-8.

Aurora B and condensin are dispensable for chromosome arm and telomere separation during meiosis II.

Berthezene J, Reyes C, Li T, Coulon S, Bernard P, Gachet Y Mol Biol Cell. 2020; 31(9):889-905.

PMID: 32101485 PMC: 7185977. DOI: 10.1091/mbc.E20-01-0021.

Nuclear envelope attachment of telomeres limits TERRA and telomeric rearrangements in quiescent fission yeast cells.

Maestroni L, Reyes C, Vaurs M, Gachet Y, Tournier S, Geli V Nucleic Acids Res. 2020; 48(6):3029-3041.

PMID: 31980821 PMC: 7102995. DOI: 10.1093/nar/gkaa043.

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