The Neuroanatomical Basis of Panic Disorder and Social Phobia in Schizophrenia: a Voxel Based Morphometric Study

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2015 Mar 17

PMID 25774979

Citations 5

Authors

Marisol Picado

Susanna Carmona

Elseline Hoekzema

Guillem Pailhez

Daniel Berge

Anna Mane

Jordi Fauquet

Joseph Hilferty

Ana Moreno

Romina Cortizo

Oscar Vilarroya

Antoni Bulbena

Affiliations

Soon will be listed here.

Abstract

Objective: It is known that there is a high prevalence of certain anxiety disorders among schizophrenic patients, especially panic disorder and social phobia. However, the neural underpinnings of the comorbidity of such anxiety disorders and schizophrenia remain unclear. Our study aims to determine the neuroanatomical basis of the co-occurrence of schizophrenia with panic disorder and social phobia.

Methods: Voxel-based morphometry was used in order to examine brain structure and to measure between-group differences, comparing magnetic resonance images of 20 anxious patients, 20 schizophrenic patients, 20 schizophrenic patients with comorbid anxiety, and 20 healthy control subjects.

Results: Compared to the schizophrenic patients, we observed smaller grey-matter volume (GMV) decreases in the dorsolateral prefrontal cortex and precentral gyrus in the schizophrenic-anxiety group. Additionally, the schizophrenic group showed significantly reduced GMV in the dorsolateral prefrontal cortex, precentral gyrus, orbitofrontal cortex, temporal gyrus and angular/inferior parietal gyrus when compared to the control group.

Conclusions: Our findings suggest that the comorbidity of schizophrenia with panic disorder and social phobia might be characterized by specific neuroanatomical and clinical alterations that may be related to maladaptive emotion regulation related to anxiety. Even thought our findings need to be replicated, our study suggests that the identification of neural abnormalities involved in anxiety, schizophrenia and schizophrenia-anxiety may lead to an improved diagnosis and management of these conditions.

Citing Articles

Gray Matter Alterations in Panic Disorder: A Voxel-Wise Meta-Analysis.

Pan A, Liu S, Hu S, Dai J, Yi J Psychiatry Clin Psychopharmacol. 2024; 33(3):229-237.

PMID: 38765308 PMC: 11082626. DOI: 10.5152/pcp.2023.23684.

Grey matter structural alterations in anxiety disorders: a voxel-based meta-analysis.

Liu H, Hao Z, Qiu S, Wang Q, Zhan L, Huang L Brain Imaging Behav. 2023; 18(2):456-474.

PMID: 38150133 DOI: 10.1007/s11682-023-00842-x.

Glutamic Acid Decarboxylase 1 Gene Methylation and Panic Disorder Severity: Making the Connection by Brain Gray Matter Volume.

Wu H, Zhong Y, Xu H, Ding H, Yuan S, Wu Y Front Psychiatry. 2022; 13:853613.

PMID: 35686186 PMC: 9170964. DOI: 10.3389/fpsyt.2022.853613.

Altered spontaneous neuronal activity and functional connectivity pattern in primary angle-closure glaucoma: a resting-state fMRI study.

Wang R, Tang Z, Liu T, Sun X, Wu L, Xiao Z Neurol Sci. 2020; 42(1):243-251.

PMID: 32632634 DOI: 10.1007/s10072-020-04577-1.

Correction: The neuroanatomical basis of panic disorder and social phobia in schizophrenia: a voxel based morphometric study.

Picado M, Carmona S, Hoekzema E, Pailhez G, Berge D, Mane A PLoS One. 2015; 10(4):e0126407.

PMID: 25906143 PMC: 4408117. DOI: 10.1371/journal.pone.0126407.

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