Alkaline Phosphatase in Stem Cells

Overview

Journal Stem Cells Int

Publisher Wiley

Specialty Cell Biology

Date 2015 Mar 14

PMID 25767512

Citations 85

Authors

Katerina Stefkova

Jirina Prochazkova

Jiri Pachernik

Affiliations

Soon will be listed here.

Abstract

Alkaline phosphatase is an enzyme commonly expressed in almost all living organisms. In humans and other mammals, determinations of the expression and activity of alkaline phosphatase have frequently been used for cell determination in developmental studies and/or within clinical trials. Alkaline phosphatase also seems to be one of the key markers in the identification of pluripotent embryonic stem as well as related cells. However, alkaline phosphatases exist in some isoenzymes and isoforms, which have tissue specific expressions and functions. Here, the role of alkaline phosphatase as a stem cell marker is discussed in detail. First, we briefly summarize contemporary knowledge of mammalian alkaline phosphatases in general. Second, we focus on the known facts of its role in and potential significance for the identification of stem cells.

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