Progression to Regular Heroin Use: Examination of Patterns, Predictors, and Consequences
Overview
Social Sciences
Affiliations
Background: The present study retrospectively evaluated the chronology and predictors of substance use progression in current heroin-using individuals.
Methods: Out-of-treatment heroin users (urinalysis-verified; N=562) were screened for laboratory-based research studies using questionnaires and urinalysis. Comprehensive substance use histories were collected. Between- and within-substance use progression was analyzed using stepwise linear regression models.
Results: The strongest predictor of onset of regular heroin use was age at initial heroin use, accounting for 71.8% of variance. The strongest between-substance predictors of regular heroin use were ages at regular alcohol and tobacco use, accounting for 8.1% of variance. Earlier onset of regular heroin use (≤20 years) vs. older onset (≥30 years) was associated with a more rapid progression from initial to regular use, longer duration of heroin use, more lifetime use-related negative consequences, and greater likelihood of injecting heroin. The majority of participants (79.7%) reported substance use progression consistent with the gateway hypothesis. Gateway-inconsistent individuals were more likely to be African-American and to report younger age at initial use, longer duration of heroin use, and more frequent past-month heroin use.
Conclusions: Our findings demonstrate the predictive validity and clinical relevance of evaluating substance use chronology and the gateway hypothesis pattern of progression.
Mediational pathways among drug use initiation, use-related consequences, and quit attempts.
Sogbesan A, Lenz D, Lister J, Lundahl L, Greenwald M, Woodcock E Drug Alcohol Depend Rep. 2024; 11:100229.
PMID: 38638305 PMC: 11024908. DOI: 10.1016/j.dadr.2024.100229.
Sichel C, Winetsky D, Campos S, OGrady M, Tross S, Kim J J Subst Abuse Treat. 2022; 143():108864.
PMID: 36242819 PMC: 11726775. DOI: 10.1016/j.jsat.2022.108864.
Reed Z, Wootton R, Munafo M Addiction. 2021; 117(3):741-750.
PMID: 34590374 PMC: 9453475. DOI: 10.1111/add.15673.
Rodriguez-Ruiz J, Zych I, Llorent V, Marin-Lopez I Int J Clin Health Psychol. 2021; 21(3):100251.
PMID: 34527057 PMC: 8417910. DOI: 10.1016/j.ijchp.2021.100251.
Effectiveness of medication for opioid use disorders in transition-age youth: A systematic review.
Becker S, Scott K, Helseth S, Danko K, Balk E, Saldanha I J Subst Abuse Treat. 2021; 132:108494.
PMID: 34098208 PMC: 8628023. DOI: 10.1016/j.jsat.2021.108494.