The Road Not Taken: Less Traveled Roads from the TGN to the Plasma Membrane

Overview

Journal Membranes (Basel)

Date 2015 Mar 13

PMID 25764365

Citations 22

Authors

Anne Spang

Affiliations

Soon will be listed here.

Abstract

The trans-Golgi network functions in the distribution of cargo into different transport vesicles that are destined to endosomes, lysosomes and the plasma membrane. Over the years, it has become clear that more than one transport pathway promotes plasma membrane localization of proteins. In spite of the importance of temporal and spatial control of protein localization at the plasma membrane, the regulation of sorting into and the formation of different transport containers are still poorly understood. In this review different transport pathways, with a special emphasis on exomer-dependent transport, and concepts of regulation and sorting at the TGN are discussed.

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References

Kent H, Evans P, Schafer I, Gray S, Sanderson C, Luzio J . Structural basis of the intracellular sorting of the SNARE VAMP7 by the AP3 adaptor complex. Dev Cell. 2012; 22(5):979-88. PMC: 3549491. DOI: 10.1016/j.devcel.2012.01.018. View

Bonifacino J . Adaptor proteins involved in polarized sorting. J Cell Biol. 2014; 204(1):7-17. PMC: 3882786. DOI: 10.1083/jcb.201310021. View

Tomas A, Futter C, Eden E . EGF receptor trafficking: consequences for signaling and cancer. Trends Cell Biol. 2013; 24(1):26-34. PMC: 3884125. DOI: 10.1016/j.tcb.2013.11.002. View

Surma M, Klose C, Simons K . Lipid-dependent protein sorting at the trans-Golgi network. Biochim Biophys Acta. 2012; 1821(8):1059-67. DOI: 10.1016/j.bbalip.2011.12.008. View

Daboussi L, Costaguta G, Payne G . Phosphoinositide-mediated clathrin adaptor progression at the trans-Golgi network. Nat Cell Biol. 2012; 14(3):239-48. PMC: 4855891. DOI: 10.1038/ncb2427. View

Chuang J, Schekman R . Differential trafficking and timed localization of two chitin synthase proteins, Chs2p and Chs3p. J Cell Biol. 1996; 135(3):597-610. PMC: 2121060. DOI: 10.1083/jcb.135.3.597. View

Sacristan C, Manzano-Lopez J, Reyes A, Spang A, Muniz M, Roncero C . Oligomerization of the chitin synthase Chs3 is monitored at the Golgi and affects its endocytic recycling. Mol Microbiol. 2013; 90(2):252-66. DOI: 10.1111/mmi.12360. View

Cohen A, Combs T, Scherer P, Lisanti M . Role of caveolin and caveolae in insulin signaling and diabetes. Am J Physiol Endocrinol Metab. 2003; 285(6):E1151-60. DOI: 10.1152/ajpendo.00324.2003. View

Sanchatjate S, Schekman R . Chs5/6 complex: a multiprotein complex that interacts with and conveys chitin synthase III from the trans-Golgi network to the cell surface. Mol Biol Cell. 2006; 17(10):4157-66. PMC: 1635352. DOI: 10.1091/mbc.e06-03-0210. View

10.

DSouza R, Semus R, Billings E, Meyer C, Conger K, Casanova J . Rab4 orchestrates a small GTPase cascade for recruitment of adaptor proteins to early endosomes. Curr Biol. 2014; 24(11):1187-98. PMC: 4059052. DOI: 10.1016/j.cub.2014.04.003. View

11.

Puertollano R, van der Wel N, Greene L, Eisenberg E, Peters P, Bonifacino J . Morphology and dynamics of clathrin/GGA1-coated carriers budding from the trans-Golgi network. Mol Biol Cell. 2003; 14(4):1545-57. PMC: 153121. DOI: 10.1091/mbc.02-07-0109. View

12.

Polishchuk R, San Pietro E, Di Pentima A, Tete S, Bonifacino J . Ultrastructure of long-range transport carriers moving from the trans Golgi network to peripheral endosomes. Traffic. 2006; 7(8):1092-103. DOI: 10.1111/j.1600-0854.2006.00453.x. View

13.

Kupfer L, Hinrichs W, Groschup M . Prion protein misfolding. Curr Mol Med. 2009; 9(7):826-35. PMC: 3330701. DOI: 10.2174/156652409789105543. View

14.

Anitei M, Hoflack B . Bridging membrane and cytoskeleton dynamics in the secretory and endocytic pathways. Nat Cell Biol. 2011; 14(1):11-9. DOI: 10.1038/ncb2409. View

15.

Gravotta D, Carvajal-Gonzalez J, Mattera R, Deborde S, Banfelder J, Bonifacino J . The clathrin adaptor AP-1A mediates basolateral polarity. Dev Cell. 2012; 22(4):811-23. PMC: 3690600. DOI: 10.1016/j.devcel.2012.02.004. View

16.

Park Y, Kim K . Short-term plasticity of small synaptic vesicle (SSV) and large dense-core vesicle (LDCV) exocytosis. Cell Signal. 2009; 21(10):1465-70. DOI: 10.1016/j.cellsig.2009.02.015. View

17.

Asensio C, Sirkis D, Edwards R . RNAi screen identifies a role for adaptor protein AP-3 in sorting to the regulated secretory pathway. J Cell Biol. 2010; 191(6):1173-87. PMC: 3002028. DOI: 10.1083/jcb.201006131. View

18.

Ebel J, Beuter S, Wuchter J, Kriebel M, Volkmer H . Organisation and control of neuronal connectivity and myelination by cell adhesion molecule neurofascin. Adv Neurobiol. 2014; 8:231-47. DOI: 10.1007/978-1-4614-8090-7_10. View

19.

Trautwein M, Schindler C, Gauss R, Dengjel J, Hartmann E, Spang A . Arf1p, Chs5p and the ChAPs are required for export of specialized cargo from the Golgi. EMBO J. 2006; 25(5):943-54. PMC: 1409733. DOI: 10.1038/sj.emboj.7601007. View

20.

Friant S, Pecheur E, Eugster A, Michel F, Lefkir Y, Nourrisson D . Ent3p Is a PtdIns(3,5)P2 effector required for protein sorting to the multivesicular body. Dev Cell. 2003; 5(3):499-511. DOI: 10.1016/s1534-5807(03)00238-7. View