New Frontiers for Platelet CD154

Overview

Journal Exp Hematol Oncol

Publisher Biomed Central

Specialty Hematology

Date 2015 Mar 13

PMID 25763299

Citations 15

Authors

Antoine Dewitte

Annabelle Tanga

Julien Villeneuve

Sebastien Lepreux

Alexandre Ouattara

Alexis Desmouliere

Christian Combe

Jean Ripoche

Affiliations

Soon will be listed here.

Abstract

The role of platelets extends beyond hemostasis. The pivotal role of platelets in inflammation has shed new light on the natural history of conditions associated with acute or chronic inflammation. Beyond the preservation of vascular integrity, platelets are essential to tissue homeostasis and platelet-derived products are already used in the clinics. Unanticipated was the role of platelets in the adaptative immune response, allowing a renewed conceptual approach of auto-immune diseases. Platelets are also important players in cancer growth and dissemination. Platelets fulfill most of their functions through the expression of still incompletely characterized membrane-bound or soluble mediators. Among them, CD154 holds a peculiar position, as platelets represent a major source of CD154 and as CD154 contributes to most of these new platelet attributes. Here, we provide an overview of some of the new frontiers that the study of platelet CD154 is opening, in inflammation, tissue homeostasis, immune response, hematopoiesis and cancer.

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