Satellite Cells: Regenerative Mechanisms and Applicability in Muscular Dystrophy

Overview

Journal Stem Cells Int

Publisher Wiley

Specialty Cell Biology

Date 2015 Mar 13

PMID 25763072

Citations 6

Authors

Gustavo Torres de Souza

Rafaella de Souza Salomao Zanette

Danielle Luciana Aurora Soares do Amaral

Francisco Carlos da Guia

Claudineia Pereira Maranduba

Camila Maurmann de Souza

Ernesto da Silveira Goulart Guimaraes

Joao Vitor Paes Rettore

Natana Chaves Rabelo

Antonio Marcio Resende do Carmo

Fernando de Sa Silva

Carlos Magno da Costa Maranduba

Affiliations

Soon will be listed here.

Abstract

The satellite cells are long regarded as heterogeneous cell population, which is intimately linked to the processes of muscular recovery. The heterogeneous cell population may be classified by specific markers. In spite of the significant amount of variation amongst the satellite cell populations, it seems that their activity is tightly bound to the paired box 7 transcription factor expression, which is, therefore, used as a canonical marker for these cells. Muscular dystrophic diseases, such as Duchenne muscular dystrophy, elicit severe tissue injuries leading those patients to display a very specific pattern of muscular recovery abnormalities. There have been works on the application of precursors cells as a therapeutic alternative for Duchenne muscular dystrophy and initial attempts have proven the cells inefficient; however later endeavours have proposed solutions for the experiments improving significantly the results. The presence of a range of satellite cells populations indicates the existence of specific cells with enhanced capability of muscular recovery in afflicted muscles.

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