Changes in Pulmonary Function and Controlled Ventilation-High Resolution CT of Chest After Antibiotic Therapy in Infants and Young Children with Cystic Fibrosis

Overview

Journal Lung

Specialty Pulmonary Medicine

Date 2015 Mar 13

PMID 25762451

Citations 2

Authors

Shahid I Sheikh

Frederick R Long

Robert Flucke

Nancy A Ryan-Wenger

Don Hayes Jr

Karen S McCoy

Affiliations

Soon will be listed here.

Abstract

Background: Infants with cystic fibrosis (CF) develop early progressive lung disease which may be asymptomatic. Infant pulmonary function tests (IPFT) and controlled ventilation-high resolution computed tomography (CV-HRCT) of chest can detect early asymptomatic lung disease. It is not well established that these objective measures can detect changes in lung disease after clinical interventions.

Objective: The purpose of this study was to evaluate usefulness of IPFT and CV-HRCT to detect changes in lung disease after intravenous (IV) antibiotic therapy in infants with early CF-related lung disease.

Study Design: IPFTs and CV-HRCT done before and after 2 weeks of IV antibiotics in infants at our institution over the last 12 years were compared. CV-HRCTs were compared using the modified Brody scoring system.

Results: The sample included 21 infants, mean age 85.2 ± 47.6 weeks. Mean change in weight was 0.4 ± 0.38 kg (p = 0.001). Significant changes in IPFT included mean % predicted FEV(0.5) (+13.5 %, p = 0.043), mean %FEF(25-75) (+30.2 %, p = 0.008), mean %RV/TLC (-11.2 %, p = 0.008), and mean %FRC/TLC (-4.5 %, p = 0.001). Total Brody scores improved from a median of 10 to 5 (p < 0.001) as did mean scores for airway wall thickening (p = 0.050), air trapping (p < 0.001), and parenchymal opacities (p = 0.003).

Conclusion: IPFT and CV-HRCT can be used as objective measures of improvement in lung disease for infants with CF treated with antibiotics.

Citing Articles

Lung function imaging methods in Cystic Fibrosis pulmonary disease.

Kolodziej M, de Veer M, Cholewa M, Egan G, Thompson B Respir Res. 2017; 18(1):96.

PMID: 28514950 PMC: 5436457. DOI: 10.1186/s12931-017-0578-x.

Early pulmonary disease manifestations in cystic fibrosis mice.

Darrah R, Mitchell A, Campanaro C, Barbato E, Litman P, Sattar A J Cyst Fibros. 2016; 15(6):736-744.

PMID: 27231029 PMC: 5121081. DOI: 10.1016/j.jcf.2016.05.002.

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