GM1 Ganglioside: Past Studies and Future Potential

Overview

Journal Mol Neurobiol

Specialties Molecular Biology
Neurology

Date 2015 Mar 13

PMID 25762012

Citations 49

Authors

Massimo Aureli

Laura Mauri

Maria Grazia Ciampa

Alessandro Prinetti

Gino Toffano

Cynthia Secchieri

Sandro Sonnino

Affiliations

Soon will be listed here.

Abstract

Gangliosides (sialic acid-containing glycosphingolipids) are abundant in neurons of all animal species and play important roles in many cell physiological processes, including differentiation, memory control, cell signaling, neuronal protection, neuronal recovery, and apoptosis. Gangliosides also function as anchors or entry points for various toxins, bacteria, viruses, and autoantibodies. GM1, a ganglioside component of mammalian brains, is present mainly in neurons. GM1 is one of the best studied gangliosides, and our understanding of its properties is extensive. Simple and rapid procedures are available for preparation of GM1 as a natural compound on a large scale, or as a derivative containing an isotopic radionuclide or a specific probe. Great research interest in the properties of GM1 arose from the discovery in the early 1970s of its role as receptor for the bacterial toxin responsible for cholera pathogenesis.

Citing Articles

Evaluation of the Landscape of Pharmacodynamic Biomarkers in GM1 and GM2 Gangliosidosis.

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Sphingolipids: Less Enigmatic but Still Many Questions about the Role(s) of Ceramide in the Synthesis/Function of the Ganglioside Class of Glycosphingolipids.

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Alpha-Synuclein and GM1 Ganglioside Co-Localize in Neuronal Cytosol Leading to Inverse Interaction-Relevance to Parkinson's Disease.

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Serotonin Signaling through Lipid Membranes.

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GM1 ganglioside exerts protective effects against glutamate-excitotoxicity via its oligosaccharide in wild-type and amyotrophic lateral sclerosis motor neurons.

Lunghi G, Di Biase E, Carsana E, Henriques A, Callizot N, Mauri L FEBS Open Bio. 2023; 13(12):2324-2341.

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