MicroRNA-200b As a Switch for Inducible Adult Angiogenesis

Overview

Journal Antioxid Redox Signal

Specialty Endocrinology

Date 2015 Mar 13

PMID 25761972

Citations 19

Authors

Mithun Sinha

Subhadip Ghatak

Sashwati Roy

Chandan K Sen

Affiliations

Soon will be listed here.

Abstract

Significance: Angiogenesis is the process by which new blood vessels develop from a pre-existing vascular system. It is required for physiological processes such as developmental biology and wound healing. Angiogenesis also plays a crucial role in pathological conditions such as tumor progression. The underlying importance of angiogenesis necessitates a highly regulated process.

Recent Advances: Recent works have demonstrated that the process of angiogenesis is regulated by small noncoding RNA molecules called microRNAs (miRs). These miRs, collectively referred to as angiomiRs, have been reported to have a profound effect on the process of angiogenesis by acting as either pro-angiogenic or anti-angiogenic regulators.

Critical Issues: In this review, we will discuss the role of miR-200b as a regulator of angiogenesis. Once the process of angiogenesis is complete, anti-angiogenic miR-200b has been reported to provide necessary braking. Downregulation of miR-200b has been reported across various tumor types, as deregulated angiogenesis is necessary for tumor development. Transient downregulation of miR-200b in wounds drives wound angiogenesis.

Future Directions: New insights and understanding of the molecular mechanism of regulation of angiogenesis by miR-200b has opened new avenues of possible therapeutic interventions to treat angiogenesis-related patho-physiological conditions. Antioxid. Redox Signal. 22, 1257-1272.

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References

Qin G, Kishore R, Dolan C, Silver M, Wecker A, Luedemann C . Cell cycle regulator E2F1 modulates angiogenesis via p53-dependent transcriptional control of VEGF. Proc Natl Acad Sci U S A. 2006; 103(29):11015-20. PMC: 1544166. DOI: 10.1073/pnas.0509533103. View

De Val S, Black B . Transcriptional control of endothelial cell development. Dev Cell. 2009; 16(2):180-95. PMC: 2728550. DOI: 10.1016/j.devcel.2009.01.014. View

Chan Y, Roy S, Khanna S, Sen C . Downregulation of endothelial microRNA-200b supports cutaneous wound angiogenesis by desilencing GATA binding protein 2 and vascular endothelial growth factor receptor 2. Arterioscler Thromb Vasc Biol. 2012; 32(6):1372-82. PMC: 3399424. DOI: 10.1161/ATVBAHA.112.248583. View

Borchert G, Lanier W, Davidson B . RNA polymerase III transcribes human microRNAs. Nat Struct Mol Biol. 2006; 13(12):1097-101. DOI: 10.1038/nsmb1167. View

Krek A, Grun D, Poy M, Wolf R, Rosenberg L, Epstein E . Combinatorial microRNA target predictions. Nat Genet. 2005; 37(5):495-500. DOI: 10.1038/ng1536. View

Hibino N, Yi T, Duncan D, Rathore A, Dean E, Naito Y . A critical role for macrophages in neovessel formation and the development of stenosis in tissue-engineered vascular grafts. FASEB J. 2011; 25(12):4253-63. PMC: 3236622. DOI: 10.1096/fj.11-186585. View

Chen Y, Gorski D . Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5. Blood. 2007; 111(3):1217-26. PMC: 2214763. DOI: 10.1182/blood-2007-07-104133. View

Holmes D, Zachary I . The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease. Genome Biol. 2005; 6(2):209. PMC: 551528. DOI: 10.1186/gb-2005-6-2-209. View

Baffa R, Fassan M, Volinia S, OHara B, Liu C, Palazzo J . MicroRNA expression profiling of human metastatic cancers identifies cancer gene targets. J Pathol. 2009; 219(2):214-21. DOI: 10.1002/path.2586. View

10.

Jafarifar F, Yao P, Eswarappa S, Fox P . Repression of VEGFA by CA-rich element-binding microRNAs is modulated by hnRNP L. EMBO J. 2011; 30(7):1324-34. PMC: 3094116. DOI: 10.1038/emboj.2011.38. View

11.

Lange S, Heger J, Euler G, Wartenberg M, Piper H, Sauer H . Platelet-derived growth factor BB stimulates vasculogenesis of embryonic stem cell-derived endothelial cells by calcium-mediated generation of reactive oxygen species. Cardiovasc Res. 2008; 81(1):159-68. DOI: 10.1093/cvr/cvn258. View

12.

Ceppi P, Mudduluru G, Kumarswamy R, Rapa I, Scagliotti G, Papotti M . Loss of miR-200c expression induces an aggressive, invasive, and chemoresistant phenotype in non-small cell lung cancer. Mol Cancer Res. 2010; 8(9):1207-16. DOI: 10.1158/1541-7786.MCR-10-0052. View

13.

Chen S, Feng B, George B, Chakrabarti R, Chen M, Chakrabarti S . Transcriptional coactivator p300 regulates glucose-induced gene expression in endothelial cells. Am J Physiol Endocrinol Metab. 2009; 298(1):E127-37. DOI: 10.1152/ajpendo.00432.2009. View

14.

Mukhopadhyay D, Tsiokas L, Sukhatme V . Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression. Cancer Res. 1995; 55(24):6161-5. View

15.

Sen C . MicroRNAs as new maestro conducting the expanding symphony orchestra of regenerative and reparative medicine. Physiol Genomics. 2011; 43(10):517-20. PMC: 3110892. DOI: 10.1152/physiolgenomics.00037.2011. View

16.

Das A, Ganesh K, Khanna S, Sen C, Roy S . Engulfment of apoptotic cells by macrophages: a role of microRNA-21 in the resolution of wound inflammation. J Immunol. 2014; 192(3):1120-9. PMC: 4358325. DOI: 10.4049/jimmunol.1300613. View

17.

Ball S, Shuttleworth C, Kielty C . Mesenchymal stem cells and neovascularization: role of platelet-derived growth factor receptors. J Cell Mol Med. 2007; 11(5):1012-30. PMC: 4401270. DOI: 10.1111/j.1582-4934.2007.00120.x. View

18.

Schickel R, Park S, Murmann A, Peter M . miR-200c regulates induction of apoptosis through CD95 by targeting FAP-1. Mol Cell. 2010; 38(6):908-15. PMC: 2904349. DOI: 10.1016/j.molcel.2010.05.018. View

19.

Rysa J, Tenhunen O, Serpi R, Soini Y, Nemer M, Leskinen H . GATA-4 is an angiogenic survival factor of the infarcted heart. Circ Heart Fail. 2010; 3(3):440-50. DOI: 10.1161/CIRCHEARTFAILURE.109.889642. View

20.

Li Y, Song Y, Li F, Yang T, Lu Y, Geng Y . MicroRNA-221 regulates high glucose-induced endothelial dysfunction. Biochem Biophys Res Commun. 2009; 381(1):81-3. PMC: 2670889. DOI: 10.1016/j.bbrc.2009.02.013. View