Family History of Skin Cancer is Associated with Increased Risk of Cutaneous Squamous Cell Carcinoma

Overview

Journal Dermatol Surg

Date 2015 Mar 12

PMID 25760557

Citations 14

Authors

Maryam M Asgari

E Margaret Warton

Alice S Whittemore

Affiliations

Soon will be listed here.

Abstract

Background: The contribution of family history to cutaneous squamous cell carcinoma (SCC) risk has not been systematically quantified.

Objective: To examine the association between self-reported family history of skin cancer and SCC risk.

Methods And Materials: Cases (n = 415) with a pathology-verified SCC and 415 age-, gender-, and race-matched controls were identified within a large integrated health care delivery system. Family history and skin cancer risk factors were ascertained by survey. Odds ratios (ORs) for associations of SCC with family history of skin cancer were estimated using conditional logistic regression adjusted for environmental and innate SCC risk factors.

Results: Any known family history of skin cancer was associated with a four-fold higher risk of SCC, adjusting for known environmental and innate SCC risk factors (OR, 4.0; confidence interval [CI]: 2.5-6.5). An unknown family history of skin cancer showed similar risk for SCC (OR, 3.9; CI: 2.4-6.5). In models including skin cancer type, the strongest association was for family history of basal cell carcinoma (OR, 9.8; CI: 2.6-36.8) and for multiple skin cancer types (OR, 10.5; CI: 3.7-29.6).

Conclusion: Family history of skin cancer is an important independent risk factor for cutaneous SCCs.

Citing Articles

Sun Safety Knowledge, Practices, and Attitudes in the West of Iranian Farmers in 2024: A Cross-Sectional Study.

Bidarpoor F, Farazandeh H, Ghaderi P, Ebrahimi K, Mahmoodi H Health Sci Rep. 2025; 8(2):e70446.

PMID: 39957971 PMC: 11825973. DOI: 10.1002/hsr2.70446.

Exosomal Non-coding RNAs: A New Approach to Melanoma Diagnosis and Therapeutic Strategy.

Liu J, Hu X, Xin W, Wang X Curr Med Chem. 2023; 31(37):6084-6109.

PMID: 37877505 DOI: 10.2174/0109298673267553231017053329.

Systematic review on gene-sun exposure interactions in skin cancer.

Shraim R, Farran M, He G, Marunica Karsaj J, Zgaga L, McManus R Mol Genet Genomic Med. 2023; 11(10):e2259.

PMID: 37537768 PMC: 10568388. DOI: 10.1002/mgg3.2259.

Microbiota, Oxidative Stress, and Skin Cancer: An Unexpected Triangle.

Azzimonti B, Ballacchino C, Zanetta P, Cucci M, Monge C, Grattarola M Antioxidants (Basel). 2023; 12(3).

PMID: 36978794 PMC: 10045429. DOI: 10.3390/antiox12030546.

Maternal high-cholesterol diet negatively programs offspring bone development and downregulates hedgehog signaling in osteoblasts.

Mangu S, Patel K, Sukhdeo S, Savitha M, Sharan K J Biol Chem. 2022; 298(9):102324.

PMID: 35931113 PMC: 9440389. DOI: 10.1016/j.jbc.2022.102324.

References

Ferreira F, Nascimento L, Rotta O . Risk factors for nonmelanoma skin cancer in Taubaté, São Paulo, Brazil: a case-control study. Rev Assoc Med Bras (1992). 2011; 57(4):424-30. View

Asgari M, Chren M, Warton E, Friedman G, White E . Association between nonsteroidal anti-inflammatory drug use and cutaneous squamous cell carcinoma. Arch Dermatol. 2010; 146(4):388-95. PMC: 2857681. DOI: 10.1001/archdermatol.2009.374. View

Floderus B, Barlow L, Mack T . Recall bias in subjective reports of familial cancer. Epidemiology. 1990; 1(4):318-21. DOI: 10.1097/00001648-199007000-00011. View

Preston D, Stern R . Nonmelanoma cancers of the skin. N Engl J Med. 1992; 327(23):1649-62. DOI: 10.1056/NEJM199212033272307. View

Goudie D, DAlessandro M, Merriman B, Lee H, Szeverenyi I, Avery S . Multiple self-healing squamous epithelioma is caused by a disease-specific spectrum of mutations in TGFBR1. Nat Genet. 2011; 43(4):365-9. DOI: 10.1038/ng.780. View

Hemminki K, Zhang H, Czene K . Familial invasive and in situ squamous cell carcinoma of the skin. Br J Cancer. 2003; 88(9):1375-80. PMC: 2741043. DOI: 10.1038/sj.bjc.6600909. View

Satia-Abouta J, Patterson R, King I, Stratton K, Shattuck A, Kristal A . Reliability and validity of self-report of vitamin and mineral supplement use in the vitamins and lifestyle study. Am J Epidemiol. 2003; 157(10):944-54. DOI: 10.1093/aje/kwg039. View

Wang L, Xiong P, Strom S, Goldberg L, Lee J, Ross M . In vitro sensitivity to ultraviolet B light and skin cancer risk: a case-control analysis. J Natl Cancer Inst. 2005; 97(24):1822-31. DOI: 10.1093/jnci/dji429. View

White E, Patterson R, Kristal A, Thornquist M, King I, Shattuck A . VITamins And Lifestyle cohort study: study design and characteristics of supplement users. Am J Epidemiol. 2003; 159(1):83-93. DOI: 10.1093/aje/kwh010. View

10.

Hogan D, Lane P, GRAN L, Wong D . Risk factors for squamous cell carcinoma of the skin in Saskatchewan, Canada. J Dermatol Sci. 1990; 1(2):97-101. DOI: 10.1016/0923-1811(90)90222-y. View

11.

Hussain S, Sundquist J, Hemminki K . The effect of having an affected parent or sibling on invasive and in situ skin cancer risk in Sweden. J Invest Dermatol. 2009; 129(9):2142-7. DOI: 10.1038/jid.2009.31. View