The Multifaceted Role of Commensal Microbiota in Homeostasis and Gastrointestinal Diseases

Overview

Journal J Immunol Res

Publisher Wiley

Specialty Allergy & Immunology

Date 2015 Mar 12

PMID 25759839

Citations 26

Authors

Marcelo Jose Barbosa Silva

Matheus Batista Heitor Carneiro

Brunna Dos Anjos Pultz

Danielle Pereira Silva

Mateus Eustaquio de Moura Lopes

Liliane Martins Dos Santos

Affiliations

Soon will be listed here.

Abstract

The gastrointestinal tract houses a complex and diverse community of microbes. In recent years, an increased understanding of the importance of intestinal microbiota for human physiology has been gained. In the steady state, commensal microorganisms have a symbiotic relationship with the host and possess critical and distinct functions, including directly influencing immunity. This means that recognition of commensal antigens is necessary for the development of complete immune responses. Therefore, the immune system must face the challenge of maintaining mucosal homeostasis while dealing with undue passage of commensal or pathogenic microbes, as well as the host nutritional status or drug use. Disruption of this fine balance has been associated with the development of several intestinal inflammatory diseases. In this review, we discuss the mechanisms involved in the modulation of host-microbe interactions and how the breakdown of this homeostatic association can lead to intestinal inflammation and pathology.

Citing Articles

Effect of oral administration of microcin Y on growth performance, intestinal barrier function and gut microbiota of chicks challenged with Salmonella Pullorum.

Li W, Zeng Z, Zhou D, Wang G, Wang Z, Li Y Vet Res. 2024; 55(1):66.

PMID: 38778424 PMC: 11112776. DOI: 10.1186/s13567-024-01321-x.

Dissecting the respective roles of microbiota and host genetics in the susceptibility of Card9 mice to colitis.

Danne C, Lamas B, Lavelle A, Michel M, Da Costa G, Pham H Microbiome. 2024; 12(1):76.

PMID: 38649950 PMC: 11036619. DOI: 10.1186/s40168-024-01798-w.

promotes CRC by down-regulating tumor cell-intrinsic PD-1 receptor via autophagy.

Qu J, Chen Q, Bing Z, Shen S, Hou Y, Lv M J Cancer. 2023; 14(10):1794-1808.

PMID: 37476193 PMC: 10355211. DOI: 10.7150/jca.79664.

Modulating AHR function offers exciting therapeutic potential in gut immunity and inflammation.

Chen Y, Wang Y, Fu Y, Yin Y, Xu K Cell Biosci. 2023; 13(1):85.

PMID: 37179416 PMC: 10182712. DOI: 10.1186/s13578-023-01046-y.

Correlation Between Serum and Urine Biomarkers and the Intensity of Acute Radiation Cystitis in Patients Treated With Radiation Therapy for Localized Prostate Cancer: Protocol for the Radiotoxicity Bladder Biomarkers (RABBIO) Study.

Helissey C, Cavallero S, Mondot S, Parnot C, Yssaad H, Becherirat S JMIR Res Protoc. 2023; 12:e38362.

PMID: 36626198 PMC: 9874987. DOI: 10.2196/38362.

References

Maslowski K, Vieira A, Ng A, Kranich J, Sierro F, Yu D . Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature. 2009; 461(7268):1282-6. PMC: 3256734. DOI: 10.1038/nature08530. View

Wu G, Chen J, Hoffmann C, Bittinger K, Chen Y, Keilbaugh S . Linking long-term dietary patterns with gut microbial enterotypes. Science. 2011; 334(6052):105-8. PMC: 3368382. DOI: 10.1126/science.1208344. View

Croswell A, Amir E, Teggatz P, Barman M, Salzman N . Prolonged impact of antibiotics on intestinal microbial ecology and susceptibility to enteric Salmonella infection. Infect Immun. 2009; 77(7):2741-53. PMC: 2708550. DOI: 10.1128/IAI.00006-09. View

Schulz O, Jaensson E, Persson E, Liu X, Worbs T, Agace W . Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions. J Exp Med. 2009; 206(13):3101-14. PMC: 2806467. DOI: 10.1084/jem.20091925. View

Havel P . Role of adipose tissue in body-weight regulation: mechanisms regulating leptin production and energy balance. Proc Nutr Soc. 2000; 59(3):359-71. DOI: 10.1017/s0029665100000410. View

Hoverstad T, Midtvedt T . Short-chain fatty acids in germfree mice and rats. J Nutr. 1986; 116(9):1772-6. DOI: 10.1093/jn/116.9.1772. View

Koido S, Ohkusa T, Kajiura T, Shinozaki J, Suzuki M, Saito K . Long-term alteration of intestinal microbiota in patients with ulcerative colitis by antibiotic combination therapy. PLoS One. 2014; 9(1):e86702. PMC: 3906066. DOI: 10.1371/journal.pone.0086702. View

Freter R . Experimental enteric Shigella and Vibrio infections in mice and guinea pigs. J Exp Med. 1956; 104(3):411-8. PMC: 2136576. DOI: 10.1084/jem.104.3.411. View

Manukyan G, Ghazaryan K, Ktsoyan Z, Khachatryan Z, Arakelova K, Kelly D . Elevated systemic antibodies towards commensal gut microbiota in autoinflammatory condition. PLoS One. 2008; 3(9):e3172. PMC: 2525839. DOI: 10.1371/journal.pone.0003172. View

10.

Round J, Mazmanian S . Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proc Natl Acad Sci U S A. 2010; 107(27):12204-9. PMC: 2901479. DOI: 10.1073/pnas.0909122107. View

11.

Dominguez-Bello M, Costello E, Contreras M, Magris M, Hidalgo G, Fierer N . Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci U S A. 2010; 107(26):11971-5. PMC: 2900693. DOI: 10.1073/pnas.1002601107. View

12.

Bisi-Johnson M, Obi C, Vasaikar S, Baba K, Hattori T . Molecular basis of virulence in clinical isolates of Escherichia coli and Salmonella species from a tertiary hospital in the Eastern Cape, South Africa. Gut Pathog. 2011; 3(1):9. PMC: 3125331. DOI: 10.1186/1757-4749-3-9. View

13.

Iliev I, Mileti E, Matteoli G, Chieppa M, Rescigno M . Intestinal epithelial cells promote colitis-protective regulatory T-cell differentiation through dendritic cell conditioning. Mucosal Immunol. 2009; 2(4):340-50. DOI: 10.1038/mi.2009.13. View

14.

Trompette A, Gollwitzer E, Yadava K, Sichelstiel A, Sprenger N, Ngom-Bru C . Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat Med. 2014; 20(2):159-66. DOI: 10.1038/nm.3444. View

15.

Araujo-Perez F, Mccoy A, Okechukwu C, Carroll I, Smith K, Jeremiah K . Differences in microbial signatures between rectal mucosal biopsies and rectal swabs. Gut Microbes. 2012; 3(6):530-5. PMC: 3495790. DOI: 10.4161/gmic.22157. View

16.

Martins F, Vieira A, Elian S, Arantes R, Tiago F, Sousa L . Inhibition of tissue inflammation and bacterial translocation as one of the protective mechanisms of Saccharomyces boulardii against Salmonella infection in mice. Microbes Infect. 2013; 15(4):270-9. DOI: 10.1016/j.micinf.2012.12.007. View

17.

Burke K, Lamont J . Clostridium difficile infection: a worldwide disease. Gut Liver. 2014; 8(1):1-6. PMC: 3916678. DOI: 10.5009/gnl.2014.8.1.1. View

18.

Que J, Hentges D . Effect of streptomycin administration on colonization resistance to Salmonella typhimurium in mice. Infect Immun. 1985; 48(1):169-74. PMC: 261931. DOI: 10.1128/iai.48.1.169-174.1985. View

19.

Corey G, Kabler H, Mehra P, Gupta S, Overcash J, Porwal A . Single-dose oritavancin in the treatment of acute bacterial skin infections. N Engl J Med. 2014; 370(23):2180-90. DOI: 10.1056/NEJMoa1310422. View

20.

Papa E, Docktor M, Smillie C, Weber S, Preheim S, Gevers D . Non-invasive mapping of the gastrointestinal microbiota identifies children with inflammatory bowel disease. PLoS One. 2012; 7(6):e39242. PMC: 3387146. DOI: 10.1371/journal.pone.0039242. View