Highly Efficient Water-mediated Approach to Access Benzazoles: Metal Catalyst and Base-free Synthesis of 2-substituted Benzimidazoles, Benzoxazoles, and Benzothiazoles

Overview

Journal Mol Divers

Date 2015 Mar 12

PMID 25758538

Citations 2

Authors

Manju Bala

Praveen Kumar Verma

Deepika Sharma

Neeraj Kumar

Bikram Singh

Affiliations

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Abstract

An efficient water-catalyzed method has been developed for the synthesis of 2-substituted benzimidazoles, benzoxazoles, and benzothiazoles in one step. The present method excludes the usage of toxic metal catalysts and bases to produce benzazoles in good to excellent yields. An efficient and versatile water-mediated method has been established for the synthesis of various 2-arylbenzazoles. The present protocol excludes the usage of any catalyst and additive provided excellent selectivities and yields with high functional group tolerance for the synthesis of 2-arylated benzimidazoles, benzoxazoles, and benzothiazoles. Benzazolones were also synthesized using similar reaction protocol.

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