Cryptococcus Neoformans Meningitis with Negative Cryptococcal Antigen: Evaluation of a New Immunochromatographic Detection Assay

Overview

Journal New Microbes New Infect

Publisher Elsevier

Specialty Infectious Diseases

Date 2015 Mar 11

PMID 25755893

Citations 8

Authors

O Opota

B Desgraz

A Kenfak

K Jaton

M Cavassini

G Greub

G Prodhom

S Giulieri

Affiliations

Soon will be listed here.

Abstract

Detection of cryptococcal antigen in serum or cerebrospinal fluid allows cryptococcal meningitis diagnosis within few hours with >90% sensitivity. In an HIV-positive patient with Cryptococcus neoformans meningitis, initial antigen detection by immunoagglutination was negative. We thus evaluated a new immunochromatographic detection assay that exhibited a higher sensitivity.

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