Beware of Immunohistochemistry--report of a Cytokeratin-, Desmin- and INI-1-negative Pelvic Desmoplastic Small Round Cell Tumor in a 51 Year Old Woman

Overview

Journal Int J Clin Exp Pathol

Specialty Pathology

Date 2015 Mar 11

PMID 25755805

Citations 5

Authors

Gwyneth St Soon

Fredrik Petersson

Affiliations

Soon will be listed here.

Abstract

We present a 51 year old female patient with a pelvic desmoplastic small round cell tumor with an unusual immunohistochemical profile, including absence of significant cytokeratin expression, complete negativity for desmin and widespread loss of nuclear INI-1 expression (>90% of tumor cells). The neoplastic cells were positive for epithelial membrane antigen (EMA), vimentin, and WT-1 (antibody against the C-terminus). The tumor showed classic histopathological features with no rhabdoid cells. Fluorescent in situ hybridization revealed EWSR1 gene rearrangement and absent SYT gene rearrangement. Reverse transcriptase polymerase chain reaction showed presence of EWSR1-WT1 transcript.

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