Tackling the Hepatitis B Disease Burden in India

Overview

Journal J Clin Exp Hepatol

Publisher Elsevier

Specialty Gastroenterology

Date 2015 Mar 11

PMID 25755578

Citations 52

Authors

Pankaj Puri

Affiliations

Soon will be listed here.

Abstract

Globally, approximately 240 people have been infected worldwide with hepatitis B Virus (HBV). India has approximately HBV carrier rate of 3.0% with a high prevalence rate in the tribal population. With a population of more than 1.25 billion, India has more than 37 million HBV carriers and contributes a large proportion of this HBV burden. While horizontal transmission in childhood appears to be a major route of transmission, the role of vertical transmission is probably underestimated. Blood transfusion and unsafe therapeutic injections continue to be important modes of transmission of HBV. There is a need for large field studies to better understand HBV epidemiology and identify high prevalence areas, and public health measures to prevent disease transmission and decrease the burden of the disease.

Citing Articles

Asian Perspective on Hepatitis B Virus and Hepatitis C Virus Elimination.

Kaewdech A, Charatcharoenwitthaya P, Piratvisuth T Viruses. 2025; 17(1.

PMID: 39861823 PMC: 11768638. DOI: 10.3390/v17010034.

Ensemble for evaluating diagnostic efficacy of non-invasive indices in predicting liver fibrosis in untreated hepatitis C virus population.

Kaur N, Goyal G, Garg R, Tapasvi C, Demirbaga U World J Methodol. 2024; 14(3):91058.

PMID: 39310236 PMC: 11230080. DOI: 10.5662/wjm.v14.i3.91058.

Is tattooing associated with increased seroprevalence of transfusion-transmitted infections among blood donors: A single-center study from Southeastern India.

Arjunan C, Basavarajegowda A Asian J Transfus Sci. 2024; 18(1):85-90.

PMID: 39036680 PMC: 11259337. DOI: 10.4103/ajts.ajts_94_22.

Hepatitis B in Trans-Himalayan Tribal Population: High Prevalence, High Pediatric Burden, Virologic Patterns, and Implications for Public Health Interventions.

Sharma B, Bodh V, Sharma N, Sharma R, Sachdeva A, Gupta A J Clin Exp Hepatol. 2024; 14(3):101336.

PMID: 38283704 PMC: 10809090. DOI: 10.1016/j.jceh.2023.101336.

Concealed for a Long Time on the Marches of Empires: Hepatitis B Virus Genotype I.

Marchio A, Sitbounlang P, Deharo E, Paboriboune P, Pineau P Microorganisms. 2023; 11(9).

PMID: 37764048 PMC: 10535388. DOI: 10.3390/microorganisms11092204.

References

Chowdhury A, Santra A, Chaudhuri S, Ghosh A, Banerjee P, Mazumder D . Prevalence of hepatitis B infection in the general population: a rural community based study. Trop Gastroenterol. 1999; 20(2):75-7. View

. Needlestick-prevention devices. Health Devices. 1999; 28(10):381-408. View

Singh J, Bhatia R, Khare S, Patnaik S, Biswas S, Lal S . Community studies on prevalence of HBsAg in two urban populations of southern India. Indian Pediatr. 2000; 37(2):149-52. View

Kapoor D, Saxena R, Sood B, Sarin S . Blood transfusion practices in India: results of a national survey. Indian J Gastroenterol. 2000; 19(2):64-7. View

Murhekar M, Murhekar K, Das D, Arankalle V, Sehgal S . Prevalence of hepatitis B infection among the primitive tribes of Andaman & Nicobar Islands. Indian J Med Res. 2000; 111:199-203. View

Chandrasekaran S, Palaniappan N, Krishnan V, Mohan G, Chandrasekaran N . Relative prevalence of hepatitis B viral markers and hepatitis C virus antibodies (anti HCV) in Madurai, south India. Indian J Med Sci. 2001; 54(7):270-3. View

Merican I, Guan R, Amarapuka D, Alexander M, Chutaputti A, Chien R . Chronic hepatitis B virus infection in Asian countries. J Gastroenterol Hepatol. 2001; 15(12):1356-61. DOI: 10.1046/j.1440-1746.2000.0150121356.x. View

Lodha R, Jain Y, Anand K, Kabra S, Pandav C . Hepatitis B in India: a review of disease epidemiology. Indian Pediatr. 2001; 38(4):349-71. View

Garg S, Mathur D, Garg D . Comparison of seropositivity of HIV, HBV, HCV and syphilis in replacement and voluntary blood donors in western India. Indian J Pathol Microbiol. 2002; 44(4):409-12. View

10.

Lok A . Chronic hepatitis B. N Engl J Med. 2002; 346(22):1682-3. DOI: 10.1056/NEJM200205303462202. View

11.

Dutta R, Sen S . A study of Australia antigen, cold antibodies and ABO blood group frequencies in Ladakhies. Indian J Med Res. 1975; 63(11):1635-40. View

12.

Murhekar M, Murhekar K, Sehgal S . Alarming prevalence of hepatitis-B infection among the Jarawas--a primitive Negrito tribe of Andaman and Nicobar Islands, India. J Viral Hepat. 2003; 10(3):232-3. DOI: 10.1046/j.1365-2893.2003.00419.x. View

13.

Singh H, Pradhan M, Singh R, Phadke S, Naik S, Aggarwal R . High frequency of hepatitis B virus infection in patients with beta-thalassemia receiving multiple transfusions. Vox Sang. 2003; 84(4):292-9. DOI: 10.1046/j.1423-0410.2003.00300.x. View

14.

Rajasekaran M, Sivagnanam G, Thirumalaikolundusubramainan P, Namasivayam K, Ravindranath C . Injection practices in southern part of India. Public Health. 2003; 117(3):208-13. DOI: 10.1016/S0033-3506(03)00065-9. View

15.

Elavia A, Banker D . Hepatitis B virus infection in hospital personnel. Natl Med J India. 1992; 5(6):265-8. View

16.

Lavanchy D . Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J Viral Hepat. 2004; 11(2):97-107. DOI: 10.1046/j.1365-2893.2003.00487.x. View

17.

Chandra M, Khaja M, Farees N, Poduri C, Hussain M, Habeeb M . Prevalence, risk factors and genotype distribution of HCV and HBV infection in the tribal population: a community based study in south India. Trop Gastroenterol. 2004; 24(4):193-5. View

18.

Wai C, Fontana R . Clinical significance of hepatitis B virus genotypes, variants, and mutants. Clin Liver Dis. 2004; 8(2):321-52, vi. DOI: 10.1016/j.cld.2004.02.006. View

19.

Chakravarty R, Chowdhury A, Chaudhuri S, Santra A, Neogi M, Rajendran K . Hepatitis B infection in Eastern Indian families: need for screening of adult siblings and mothers of adult index cases. Public Health. 2005; 119(7):647-54. DOI: 10.1016/j.puhe.2004.09.007. View

20.

Murhekar M, Rao R, Ghosal S, Sehgal S . Assessment of injection-related practices in a tribal community of Andaman and Nicobar Islands, India. Public Health. 2005; 119(7):655-8. DOI: 10.1016/j.puhe.2004.07.010. View