Cultured Human Retinal Pigment Epithelial Cells Express Basic Fibroblast Growth Factor and Its Receptor

Overview

Journal Curr Eye Res

Publisher Informa Healthcare

Specialty Ophthalmology

Date 1989 Oct 1

PMID 2575481

Citations 19

Authors

M D Sternfeld

J E Robertson

G D Shipley

J Tsai

J T Rosenbaum

Affiliations

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Abstract

Basic fibroblast growth factor (bFGF) has been implicated in the maintenance of neuronal differentiation, the induction of neovascularization and intravitreal proliferative diseases. We have found that human retinal pigment epithelial (RPE) cells grown in vitro transcribe the bFGF gene and synthesize a peptide that crossreacts with anti-bFGF antibodies. In culture, these cells appear to release activity with biological and biochemical properties similar to bFGF. RPE cells have specific bFGF receptors and proliferate in response to bFGF. Thus, it is possible that the RPE cell is an important source of retinal bFGF and may respond to bFGF in an autocrine manner.

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