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The Direct Activation of Human Multidrug Resistance Gene (MDR1) by Anticancer Agents

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Publisher Elsevier
Specialty Biochemistry
Date 1989 Dec 29
PMID 2575381
Citations 44
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Abstract

Enhanced expression of a multidrug-resistance gene (MDR1) is observed in some cancer patient, but any regulatory mechanisms of MDR1 gene expression in this phenomenon is not yet known. In this study, the regulation of MDR1 gene was analysed by transient expression assays in the presence of anticancer agents. We found that MDR1 promoter could be activated directly on the addition of anticancer agents including vincristine, daunomycin, adriamycin and colchicine. The results suggest that the level of MDR1 mRNA expression is associated with previous chemotherapy, including drugs that select the multidrug resistance phenotype.

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