Designing Clinical Trials for Amblyopia

Overview

Journal Vision Res

Specialty Ophthalmology

Date 2015 Mar 11

PMID 25752747

Citations 7

Authors

Jonathan M Holmes

Affiliations

Soon will be listed here.

Abstract

Randomized clinical trial (RCT) study design leads to one of the highest levels of evidence, and is a preferred study design over cohort studies, because randomization reduces bias and maximizes the chance that even unknown confounding factors will be balanced between treatment groups. Recent randomized clinical trials and observational studies in amblyopia can be taken together to formulate an evidence-based approach to amblyopia treatment, which is presented in this review. When designing future clinical studies of amblyopia treatment, issues such as regression to the mean, sample size and trial duration must be considered, since each may impact study results and conclusions.

Citing Articles

The prevalence of functional amblyopia and its related risk factors in preschool children in North-Eastern Iran.

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Factors predicting regression of visual acuity following successful treatment of anisometropic amblyopia.

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Efficacy of interventions for amblyopia: a systematic review and network meta-analysis.

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The Effect of Combined Patching and Citalopram on Visual Acuity in Adults with Amblyopia: A Randomized, Crossover, Placebo-Controlled Trial.

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'It's too late'. Is it really? Considerations for amblyopia treatment in older children.

Piano M, Simmers A Ther Adv Ophthalmol. 2019; 11:2515841419857379.

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