Evolutionary Genetics of Insect Innate Immunity

Overview

Journal Brief Funct Genomics

Publisher Oxford University Press

Date 2015 Mar 10

PMID 25750410

Citations 25

Authors

Lumi Viljakainen

Affiliations

Soon will be listed here.

Abstract

Patterns of evolution in immune defense genes help to understand the evolutionary dynamics between hosts and pathogens. Multiple insect genomes have been sequenced, with many of them having annotated immune genes, which paves the way for a comparative genomic analysis of insect immunity. In this review, I summarize the current state of comparative and evolutionary genomics of insect innate immune defense. The focus is on the conserved and divergent components of immunity with an emphasis on gene family evolution and evolution at the sequence level; both population genetics and molecular evolution frameworks are considered.

Citing Articles

Pathogen-specific social immunity is associated with erosion of individual immune function in an ant.

Masson F, Brown R, Vizueta J, Irvine T, Xiong Z, Romiguier J Nat Commun. 2024; 15(1):9260.

PMID: 39461955 PMC: 11513022. DOI: 10.1038/s41467-024-53527-4.

Hafeez M, Donnell R, Colton A, Howe D, Denver D, Martin R Insects. 2024; 15(5).

PMID: 38786867 PMC: 11122010. DOI: 10.3390/insects15050311.

Activation of immune pathways in common bed bugs, , in response to bacterial immune challenges - a transcriptomics analysis.

Meraj S, Salcedo-Porras N, Lowenberger C, Gries G Front Immunol. 2024; 15:1384193.

PMID: 38694504 PMC: 11061471. DOI: 10.3389/fimmu.2024.1384193.

Population genomics provides insights into the genetic diversity and adaptation of the Pieris rapae in China.

Zheng L, Wang H, Lin J, Zhou Y, Xiao J, Li K PLoS One. 2023; 18(11):e0294521.

PMID: 37972203 PMC: 10653512. DOI: 10.1371/journal.pone.0294521.

Interactions between innate immunity and insulin signaling affect resistance to infection in insects.

Darby A, Lazzaro B Front Immunol. 2023; 14:1276357.

PMID: 37915572 PMC: 10616485. DOI: 10.3389/fimmu.2023.1276357.

References

Keebaugh E, Schlenke T . Adaptive evolution of a novel Drosophila lectin induced by parasitic wasp attack. Mol Biol Evol. 2011; 29(2):565-77. PMC: 3258034. DOI: 10.1093/molbev/msr191. View

Bulmer M, Lay F, Hamilton C . Adaptive evolution in subterranean termite antifungal peptides. Insect Mol Biol. 2010; 19(5):669-74. DOI: 10.1111/j.1365-2583.2010.01023.x. View

Viljakainen L, Pamilo P . Selection on an antimicrobial peptide defensin in ants. J Mol Evol. 2008; 67(6):643-52. DOI: 10.1007/s00239-008-9173-6. View

Garver L, de Almeida Oliveira G, Barillas-Mury C . The JNK pathway is a key mediator of Anopheles gambiae antiplasmodial immunity. PLoS Pathog. 2013; 9(9):e1003622. PMC: 3764222. DOI: 10.1371/journal.ppat.1003622. View

Bao Y, Qu L, Zhao D, Chen L, Jin H, Xu L . The genome- and transcriptome-wide analysis of innate immunity in the brown planthopper, Nilaparvata lugens. BMC Genomics. 2013; 14:160. PMC: 3616906. DOI: 10.1186/1471-2164-14-160. View

Mikonranta L, Mappes J, Kaukoniitty M, Freitak D . Insect immunity: oral exposure to a bacterial pathogen elicits free radical response and protects from a recurring infection. Front Zool. 2014; 11(1):23. PMC: 3975449. DOI: 10.1186/1742-9994-11-23. View

Morandin C, Havukainen H, Kulmuni J, Dhaygude K, Trontti K, Helantera H . Not only for egg yolk--functional and evolutionary insights from expression, selection, and structural analyses of Formica ant vitellogenins. Mol Biol Evol. 2014; 31(8):2181-93. DOI: 10.1093/molbev/msu171. View

Sackton T, Clark A . Comparative profiling of the transcriptional response to infection in two species of Drosophila by short-read cDNA sequencing. BMC Genomics. 2009; 10:259. PMC: 2701966. DOI: 10.1186/1471-2164-10-259. View

Nielsen R, Yang Z . Likelihood models for detecting positively selected amino acid sites and applications to the HIV-1 envelope gene. Genetics. 1998; 148(3):929-36. PMC: 1460041. DOI: 10.1093/genetics/148.3.929. View

10.

Bulmer M, Crozier R . Duplication and diversifying selection among termite antifungal peptides. Mol Biol Evol. 2004; 21(12):2256-64. DOI: 10.1093/molbev/msh236. View

11.

Tennessen J . Molecular evolution of animal antimicrobial peptides: widespread moderate positive selection. J Evol Biol. 2005; 18(6):1387-94. DOI: 10.1111/j.1420-9101.2005.00925.x. View

12.

Lazzaro B, Clark A . Molecular population genetics of inducible antibacterial peptide genes in Drosophila melanogaster. Mol Biol Evol. 2003; 20(6):914-23. DOI: 10.1093/molbev/msg109. View

13.

Harpur B, Zayed A . Accelerated evolution of innate immunity proteins in social insects: adaptive evolution or relaxed constraint?. Mol Biol Evol. 2013; 30(7):1665-74. DOI: 10.1093/molbev/mst061. View

14.

Johnston P, Makarova O, Rolff J . Inducible defenses stay up late: temporal patterns of immune gene expression in Tenebrio molitor. G3 (Bethesda). 2013; 4(6):947-55. PMC: 4065263. DOI: 10.1534/g3.113.008516. View

15.

Pham L, Dionne M, Shirasu-Hiza M, Schneider D . A specific primed immune response in Drosophila is dependent on phagocytes. PLoS Pathog. 2007; 3(3):e26. PMC: 1817657. DOI: 10.1371/journal.ppat.0030026. View

16.

Simola D, Wissler L, Donahue G, Waterhouse R, Helmkampf M, Roux J . Social insect genomes exhibit dramatic evolution in gene composition and regulation while preserving regulatory features linked to sociality. Genome Res. 2013; 23(8):1235-47. PMC: 3730098. DOI: 10.1101/gr.155408.113. View

17.

Evans J, Aronstein K, Chen Y, Hetru C, Imler J, Jiang H . Immune pathways and defence mechanisms in honey bees Apis mellifera. Insect Mol Biol. 2006; 15(5):645-56. PMC: 1847501. DOI: 10.1111/j.1365-2583.2006.00682.x. View

18.

Gunaratna R, Jiang H . A comprehensive analysis of the Manduca sexta immunotranscriptome. Dev Comp Immunol. 2012; 39(4):388-98. PMC: 3595354. DOI: 10.1016/j.dci.2012.10.004. View

19.

Bishop J, Dean A, Mitchell-Olds T . Rapid evolution in plant chitinases: molecular targets of selection in plant-pathogen coevolution. Proc Natl Acad Sci U S A. 2000; 97(10):5322-7. PMC: 25827. DOI: 10.1073/pnas.97.10.5322. View

20.

Fawal N, Li Q, Mathe C, Dunand C . Automatic multigenic family annotation: risks and solutions. Trends Genet. 2014; 30(8):323-5. DOI: 10.1016/j.tig.2014.06.004. View