5' TRNA Halves: The Next Generation of Immune Signaling Molecules

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2015 Mar 7

PMID 25745425

Citations 53

Authors

Joseph Mohsen Dhahbi

Affiliations

Soon will be listed here.

Citing Articles

The Role of tRNA-Derived Small RNAs (tsRNAs) in Regulating Cell Death of Cardiovascular Diseases.

Guo J, Chen X, Ren J, Wang Y, Wang K, Yang S Biology (Basel). 2025; 14(2).

PMID: 40001986 PMC: 11853139. DOI: 10.3390/biology14020218.

The role of tRNA-Derived small RNAs (tsRNAs) in pancreatic cancer and acute pancreatitis.

Pan Y, Ying X, Zhang X, Jiang H, Yan J, Duan S Noncoding RNA Res. 2025; 11:200-208.

PMID: 39896345 PMC: 11786804. DOI: 10.1016/j.ncrna.2024.12.011.

Exploring the regulatory role of small RNAs in modulating host-pathogen interactions: implications for bacterial and viral infections.

Srinivasan R, Ramadoss R, Kandasamy V, Ranganadin P, Green S, Kasirajan A Mol Biol Rep. 2025; 52(1):115.

PMID: 39799541 DOI: 10.1007/s11033-024-10214-3.

Transfer RNA-derived fragment production in calves challenged with or co-infected with bovine viral diarrhea virus and in several tissues and blood.

Goldkamp A, Atchison R, Falkenberg S, Dassanayake R, Neill J, Casas E Front Vet Sci. 2024; 11:1463431.

PMID: 39582886 PMC: 11583443. DOI: 10.3389/fvets.2024.1463431.

Expression profiles of urine exosomal tRNA-derived small RNAs and their potential roles in calcium oxalate stone disease.

Hong S, Miao L, Yang Y, Wang S Ann Med Surg (Lond). 2024; 86(10):5802-5810.

PMID: 39359758 PMC: 11444539. DOI: 10.1097/MS9.0000000000002563.

References

Vickers K, Palmisano B, Shoucri B, Shamburek R, Remaley A . MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins. Nat Cell Biol. 2011; 13(4):423-33. PMC: 3074610. DOI: 10.1038/ncb2210. View

Zhang Y, Liu D, Chen X, Li J, Li L, Bian Z . Secreted monocytic miR-150 enhances targeted endothelial cell migration. Mol Cell. 2010; 39(1):133-44. DOI: 10.1016/j.molcel.2010.06.010. View

Selitsky S, Baran-Gale J, Honda M, Yamane D, Masaki T, Fannin E . Small tRNA-derived RNAs are increased and more abundant than microRNAs in chronic hepatitis B and C. Sci Rep. 2015; 5:7675. PMC: 4286764. DOI: 10.1038/srep07675. View

Garcia-Silva M, Cabrera-Cabrera F, Ferreira Cura das Neves R, Souto-Padron T, De Souza W, Cayota A . Gene expression changes induced by Trypanosoma cruzi shed microvesicles in mammalian host cells: relevance of tRNA-derived halves. Biomed Res Int. 2014; 2014:305239. PMC: 4000953. DOI: 10.1155/2014/305239. View

Schutz K, Hesselberth J, Fields S . Capture and sequence analysis of RNAs with terminal 2',3'-cyclic phosphates. RNA. 2010; 16(3):621-31. PMC: 2822926. DOI: 10.1261/rna.1934910. View

Haiser H, Karginov F, Hannon G, Elliot M . Developmentally regulated cleavage of tRNAs in the bacterium Streptomyces coelicolor. Nucleic Acids Res. 2007; 36(3):732-41. PMC: 2241913. DOI: 10.1093/nar/gkm1096. View

Olson K, Fett J, FRENCH T, Key M, Vallee B . Angiogenin antagonists prevent tumor growth in vivo. Proc Natl Acad Sci U S A. 1995; 92(2):442-6. PMC: 42756. DOI: 10.1073/pnas.92.2.442. View

Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee J, Lotvall J . Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007; 9(6):654-9. DOI: 10.1038/ncb1596. View

Anderson P, Ivanov P . tRNA fragments in human health and disease. FEBS Lett. 2014; 588(23):4297-304. PMC: 4339185. DOI: 10.1016/j.febslet.2014.09.001. View

10.

Thompson D, Parker R . The RNase Rny1p cleaves tRNAs and promotes cell death during oxidative stress in Saccharomyces cerevisiae. J Cell Biol. 2009; 185(1):43-50. PMC: 2700514. DOI: 10.1083/jcb.200811119. View

11.

Fu H, Feng J, Liu Q, Sun F, Tie Y, Zhu J . Stress induces tRNA cleavage by angiogenin in mammalian cells. FEBS Lett. 2008; 583(2):437-42. DOI: 10.1016/j.febslet.2008.12.043. View

12.

Dhahbi J, Spindler S, Atamna H, Yamakawa A, Guerrero N, Boffelli D . Deep sequencing identifies circulating mouse miRNAs that are functionally implicated in manifestations of aging and responsive to calorie restriction. Aging (Albany NY). 2013; 5(2):130-41. PMC: 3616200. DOI: 10.18632/aging.100540. View

13.

Dhahbi J, Spindler S, Atamna H, Boffelli D, Martin D . Deep Sequencing of Serum Small RNAs Identifies Patterns of 5' tRNA Half and YRNA Fragment Expression Associated with Breast Cancer. Biomark Cancer. 2014; 6:37-47. PMC: 4260766. DOI: 10.4137/BIC.S20764. View

14.

Thompson D, Lu C, Green P, Parker R . tRNA cleavage is a conserved response to oxidative stress in eukaryotes. RNA. 2008; 14(10):2095-103. PMC: 2553748. DOI: 10.1261/rna.1232808. View

15.

Fabbri M, Paone A, Calore F, Galli R, Gaudio E, Santhanam R . MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response. Proc Natl Acad Sci U S A. 2012; 109(31):E2110-6. PMC: 3412003. DOI: 10.1073/pnas.1209414109. View

16.

Thompson D, Parker R . Stressing out over tRNA cleavage. Cell. 2009; 138(2):215-9. DOI: 10.1016/j.cell.2009.07.001. View

17.

Ivanov P, Emara M, Villen J, Gygi S, Anderson P . Angiogenin-induced tRNA fragments inhibit translation initiation. Mol Cell. 2011; 43(4):613-23. PMC: 3160621. DOI: 10.1016/j.molcel.2011.06.022. View

18.

Horton R, Wilming L, Rand V, Lovering R, Bruford E, Khodiyar V . Gene map of the extended human MHC. Nat Rev Genet. 2004; 5(12):889-99. DOI: 10.1038/nrg1489. View

19.

Meiri E, Levy A, Benjamin H, Ben-David M, Cohen L, Dov A . Discovery of microRNAs and other small RNAs in solid tumors. Nucleic Acids Res. 2010; 38(18):6234-46. PMC: 2952848. DOI: 10.1093/nar/gkq376. View

20.

Zernecke A, Bidzhekov K, Noels H, Shagdarsuren E, Gan L, Denecke B . Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection. Sci Signal. 2009; 2(100):ra81. DOI: 10.1126/scisignal.2000610. View