The Role of Th17-associated Cytokines in the Pathogenesis of Experimental Autoimmune Uveitis (EAU)

Overview

Journal Cytokine

Specialties Allergy & Immunology
Biology

Date 2015 Mar 7

PMID 25742774

Citations 13

Authors

Deming Sun

Dongchun Liang

Henry J Kaplan

Hui Shao

Affiliations

Soon will be listed here.

Abstract

The proinflammatory and pathogenic function of Th17 cells in autoimmune diseases have been established but the mechanism by which such cells cause disease remains to be determined. Inflammatory cytokines produced by Th17 cells may either promote or inhibit disease development. The major cytokines produced by the uveitogenic T cells, such as IL-17 and IL-22, are not always pathogenic, and the disease-inducing ability of pathogenic T cells is not immediately correlated to the amount of cytokine they produce. Future studies identifying factors causing increased Th17 responses and determining the types of cells that regulating Th17 autoreactive T cells should facilitate our effort of understanding Th17-mediated disease pathogenesis.

Citing Articles

Th17 Response in Uveitis: A Double-Edged Sword in Ocular Inflammation and Immune Regulation.

Zong Y, Tong X, Chong W Clin Rev Allergy Immunol. 2025; 68(1):26.

PMID: 40072803 PMC: 11903535. DOI: 10.1007/s12016-025-09038-1.

Role of CD4 T cell-derived cytokines in the pathogenesis of uveitis.

Meng T, Nie L, Wang Y Clin Exp Med. 2025; 25(1):49.

PMID: 39909966 PMC: 11799126. DOI: 10.1007/s10238-025-01565-7.

Ocular immune-related diseases: molecular mechanisms and therapy.

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Immune cells mediate the causal relationship between uveitis and colorectal cancer via Mendelian randomization analysis.

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