Rapid Viral Rebound After 4 Years of Suppressive Therapy in a Seronegative HIV-1 Infected Infant Treated from Birth

Overview

Journal Pediatr Infect Dis J

Specialty Pediatrics

Date 2015 Mar 6

PMID 25742088

Citations 30

Authors

Karina M Butler

Patrick Gavin

Suzie Coughlan

Annette Rochford

Sinead Mc Donagh

Orla Cunningham

Hannah Poulsom

Sarah A Watters

Nigel Klein

Affiliations

Soon will be listed here.

Abstract

Attention has focused on the possibility of cure for HIV infected infants if treated promptly after delivery. The "Mississippi baby," who had very prolonged remission after antiretroviral discontinuation, may represent a unique situation. We report an infant treated from birth, who seroreverted, remained virologically suppressed, and had undetectable HIV-1 RNA and DNA at 4 years of age, yet experienced virologic rebound within days of discontinuation of antiretroviral therapy.

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