Radiotracers Used for the Scintigraphic Detection of Infection and Inflammation
Overview
Authors
Affiliations
Over the last forty years, a small group of commercial radiopharmaceuticals have found their way into routine medical use, for the diagnostic imaging of patients with infection or inflammation. These molecular radiotracers usually participate in the immune response to an antigen, by tagging leukocytes or other molecules/cells that are endogenous to the process. Currently there is an advancing effort by researchers in the preclinical domain to design and develop new agents for this application. This review discusses radiopharmaceuticals used in the nuclear medicine clinic today, as well as those potential radiotracers that exploit an organism's defence mechanisms to an infectious or inflammatory event.
Rodent Leukocyte Isolation and Radiolabeling for Inflammation Imaging Study.
Kim E, Oh P, Boud F, Jeong H, Lim S, Sohn M Nucl Med Mol Imaging. 2020; 54(3):147-155.
PMID: 32582398 PMC: 7295882. DOI: 10.1007/s13139-020-00645-8.
Multimodal Molecular Imaging of the Tumour Microenvironment.
Foray C, Barca C, Backhaus P, Schelhaas S, Winkeler A, Viel T Adv Exp Med Biol. 2020; 1225:71-87.
PMID: 32030648 DOI: 10.1007/978-3-030-35727-6_5.
Pathogen-Specific Bacterial Imaging in Nuclear Medicine.
Ordonez A, Jain S Semin Nucl Med. 2018; 48(2):182-194.
PMID: 29452620 PMC: 5819618. DOI: 10.1053/j.semnuclmed.2017.11.003.
Fuscaldi L, Santos D, Pinheiro N, Araujo R, de Barros A, Resende J J Venom Anim Toxins Incl Trop Dis. 2016; 22:16.
PMID: 27110232 PMC: 4841036. DOI: 10.1186/s40409-016-0070-y.