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Radiotracers Used for the Scintigraphic Detection of Infection and Inflammation

Overview
Publisher Wiley
Specialty Biology
Date 2015 Mar 6
PMID 25741532
Citations 4
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Abstract

Over the last forty years, a small group of commercial radiopharmaceuticals have found their way into routine medical use, for the diagnostic imaging of patients with infection or inflammation. These molecular radiotracers usually participate in the immune response to an antigen, by tagging leukocytes or other molecules/cells that are endogenous to the process. Currently there is an advancing effort by researchers in the preclinical domain to design and develop new agents for this application. This review discusses radiopharmaceuticals used in the nuclear medicine clinic today, as well as those potential radiotracers that exploit an organism's defence mechanisms to an infectious or inflammatory event.

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References
1.
Arndt J, van der Sluys Veer A, Blok D, Griffioen G, Verspaget H, Pena A . A prospective comparison of 99mTc-labeled polyclonal human immunoglobulin and 111In granulocytes for localization of inflammatory bowel disease. Acta Radiol. 1992; 33(2):140-4. View

2.
Geng X, Zhang R, Yang G, Jiang W, Xu C . Interleukin-2 and autoimmune disease occurrence and therapy. Eur Rev Med Pharmacol Sci. 2012; 16(11):1462-7. View

3.
Moser B . Chemokines: role in immune cell traffic. Eur Cytokine Netw. 2004; 14(4):204-10. View

4.
Skehan S, White J, Evans J, Parry-Jones D, Solanki C, Ballinger J . Mechanism of accumulation of 99mTc-sulesomab in inflammation. J Nucl Med. 2003; 44(1):11-8. View

5.
Gaemperli O, Shalhoub J, Owen D, Lamare F, Johansson S, Fouladi N . Imaging intraplaque inflammation in carotid atherosclerosis with 11C-PK11195 positron emission tomography/computed tomography. Eur Heart J. 2011; 33(15):1902-10. DOI: 10.1093/eurheartj/ehr367. View