Lipid Signaling in Tumorigenesis

Overview

Journal Mol Cell Pharmacol

Specialty Biochemistry

Date 2015 Mar 6

PMID 25741396

Citations 6

Authors

Renyan Liu

Ying Huang

Affiliations

Soon will be listed here.

Abstract

Lipids are important cellular building blocks and components of signaling cascades. Deregulation of lipid metabolism or signaling is frequently linked to a variety of human diseases such as diabetes, cardiovascular diseases, and cancer. It is widely believed that lipid molecules or their metabolic products are involved in tumorigenic inflammation and thus, lipids are implicated as significant contributors or even primary triggers of tumorigenesis. Lipids are believed to directly or indirectly activate growth promoting signals such as those involving LPA, insulin, IGF-1 and EGF to promote cancer cell growth. Cellular levels of certain lipids, including sphingosine-1-phosphate and ceramide, maintain a delicate balance between cell death and survival and alterations in their levels lead to unfavorable consequences including tumorigenesis. This article provides an overview of current knowledge that implicates lipids in tumorigenesis and explores the potential mechanisms that support a positive link between obesity and cancer.

Citing Articles

Promises and Challenges of Predictive Blood Biomarkers for Locally Advanced Rectal Cancer Treated with Neoadjuvant Chemoradiotherapy.

Machado Carvalho J, Dutoit V, Corro C, Koessler T Cells. 2023; 12(3).

PMID: 36766755 PMC: 9913546. DOI: 10.3390/cells12030413.

Hydroxysteroid 11-Beta Dehydrogenase 1 Overexpression with Copy-Number Gain and Missense Mutations in Primary Gastrointestinal Stromal Tumors.

Li C, Liu T, Wang J, Yu S, Chen Y, Fang F J Clin Med. 2018; 7(11).

PMID: 30388854 PMC: 6262574. DOI: 10.3390/jcm7110408.

Transcriptomic reappraisal identifies MGLL overexpression as an unfavorable prognosticator in primary gastrointestinal stromal tumors.

Li C, Chuang I, Liu T, Chen K, Chen Y, Fang F Oncotarget. 2016; 7(31):49986-49997.

PMID: 27366945 PMC: 5226563. DOI: 10.18632/oncotarget.10304.

Association between obesity and local control of advanced rectal cancer after combined surgery and radiotherapy.

Choi Y, Lee Y, Park S, Cho H, Ahn K Radiat Oncol J. 2016; 34(2):113-20.

PMID: 27306771 PMC: 4938343. DOI: 10.3857/roj.2016.01725.

Being Overweight or Obese Increases the Risk of Progression in Triple-Negative Breast Cancer after Surgical Resection.

Choi Y, Park S, Ahn K, Cho H, Kim T, Yoon H J Korean Med Sci. 2016; 31(6):886-91.

PMID: 27247497 PMC: 4853667. DOI: 10.3346/jkms.2016.31.6.886.

References

Hotamisligil G, Shargill N, Spiegelman B . Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 1993; 259(5091):87-91. DOI: 10.1126/science.7678183. View

Madhusudan S, Foster M, Muthuramalingam S, Braybrooke J, Wilner S, Kaur K . A phase II study of etanercept (Enbrel), a tumor necrosis factor alpha inhibitor in patients with metastatic breast cancer. Clin Cancer Res. 2004; 10(19):6528-34. DOI: 10.1158/1078-0432.CCR-04-0730. View

Nagle J, Ma Z, Byrne M, White M, Shaw L . Involvement of insulin receptor substrate 2 in mammary tumor metastasis. Mol Cell Biol. 2004; 24(22):9726-35. PMC: 525494. DOI: 10.1128/MCB.24.22.9726-9735.2004. View

Popivanova B, Kitamura K, Wu Y, Kondo T, Kagaya T, Kaneko S . Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis. J Clin Invest. 2008; 118(2):560-70. PMC: 2213370. DOI: 10.1172/JCI32453. View

Yedgar S, Krimsky M, Cohen Y, Flower R . Treatment of inflammatory diseases by selective eicosanoid inhibition: a double-edged sword?. Trends Pharmacol Sci. 2007; 28(9):459-64. DOI: 10.1016/j.tips.2007.07.005. View

Greenhough A, Smartt H, Moore A, Roberts H, Williams A, Paraskeva C . The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment. Carcinogenesis. 2009; 30(3):377-86. DOI: 10.1093/carcin/bgp014. View

Fox E, Miller T, Balko J, Kuba M, Sanchez V, Smith R . A kinome-wide screen identifies the insulin/IGF-I receptor pathway as a mechanism of escape from hormone dependence in breast cancer. Cancer Res. 2011; 71(21):6773-84. PMC: 3206206. DOI: 10.1158/0008-5472.CAN-11-1295. View

Andrianantoandro E, Pollard T . Mechanism of actin filament turnover by severing and nucleation at different concentrations of ADF/cofilin. Mol Cell. 2006; 24(1):13-23. DOI: 10.1016/j.molcel.2006.08.006. View

Sun H, Jiang L, Luo X, Jin W, He Q, An J . Potential tumor-suppressive role of monoglyceride lipase in human colorectal cancer. Oncogene. 2012; 32(2):234-41. PMC: 3901401. DOI: 10.1038/onc.2012.34. View

10.

Lemmon M . Membrane recognition by phospholipid-binding domains. Nat Rev Mol Cell Biol. 2008; 9(2):99-111. DOI: 10.1038/nrm2328. View

11.

Wang W, Eddy R, Condeelis J . The cofilin pathway in breast cancer invasion and metastasis. Nat Rev Cancer. 2007; 7(6):429-40. PMC: 4270061. DOI: 10.1038/nrc2148. View

12.

Chalhoub N, Baker S . PTEN and the PI3-kinase pathway in cancer. Annu Rev Pathol. 2008; 4:127-50. PMC: 2710138. DOI: 10.1146/annurev.pathol.4.110807.092311. View

13.

Subbaramaiah K, Morris P, Zhou X, Morrow M, Du B, Giri D . Increased levels of COX-2 and prostaglandin E2 contribute to elevated aromatase expression in inflamed breast tissue of obese women. Cancer Discov. 2012; 2(4):356-65. PMC: 3398487. DOI: 10.1158/2159-8290.CD-11-0241. View

14.

Maehama T . PTEN: its deregulation and tumorigenesis. Biol Pharm Bull. 2007; 30(9):1624-7. DOI: 10.1248/bpb.30.1624. View

15.

Tran T, Medline A, Bruce W . Insulin promotion of colon tumors in rats. Cancer Epidemiol Biomarkers Prev. 1996; 5(12):1013-5. View

16.

Sano H, Kawahito Y, Wilder R, Hashiramoto A, Mukai S, Asai K . Expression of cyclooxygenase-1 and -2 in human colorectal cancer. Cancer Res. 1995; 55(17):3785-9. View

17.

Chang S, Liu C, Conway R, Han D, Nithipatikom K, Trifan O . Role of prostaglandin E2-dependent angiogenic switch in cyclooxygenase 2-induced breast cancer progression. Proc Natl Acad Sci U S A. 2003; 101(2):591-6. PMC: 327192. DOI: 10.1073/pnas.2535911100. View

18.

Pollak M . The insulin and insulin-like growth factor receptor family in neoplasia: an update. Nat Rev Cancer. 2012; 12(3):159-69. DOI: 10.1038/nrc3215. View

19.

Engelman J, Luo J, Cantley L . The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet. 2006; 7(8):606-19. DOI: 10.1038/nrg1879. View

20.

Ong C, Ming-Lum A, Nodwell M, Ghanipour A, Yang L, Williams D . Small-molecule agonists of SHIP1 inhibit the phosphoinositide 3-kinase pathway in hematopoietic cells. Blood. 2007; 110(6):1942-9. DOI: 10.1182/blood-2007-03-079699. View