Catalytic Chemo-, Regio-, and Enantioselective Bromochlorination of Allylic Alcohols

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2015 Mar 5

PMID 25738419

Citations 32

Authors

Dennis X Hu

Frederick J Seidl

Cyril Bucher

Noah Z Burns

Affiliations

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Abstract

Herein we describe a highly chemo-, regio-, and enantioselective bromochlorination reaction of allylic alcohols, employing readily available halogen sources and a simple Schiff base as the chiral catalyst. The application of this interhalogenation reaction to a variety of substrates, the rapid enantioselective synthesis of a bromochlorinated natural product, and preliminary extension of this chemistry to dibromination and dichlorination are reported.

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